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Pannexin1的分布及其开放调控 被引量：3

Distribution and Regulation of Panx1 Protein
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摘要 Pannexin1(Panx1)是新型缝隙连接蛋白Pannexin家族中的成员之一,它能够在神经、心血管等系统中广泛表达并形成非选择性的、大电导的半通道。现已证明,多种条件能够调控Panx1的开放并通过释放细胞内大分子物质(如ATP)进而影响机体的生理功能。本文详细介绍了Panx1的主要存在部位,对其开放和抑制条件进行了总结归纳,并对未来的研究方向提出了建议。 Pannexinl （ Panxl ） is a subtype of the newly discovered gap junction proteins named Pannex- in（s）. Panxl is widely expressed in the nervous system, cardiovascular system, etc and can form non- selective and large conductance hemichannel. It has been demonstrated that various conditions can regu- late Panxl open and affect the body~ physiological function via macromolecular substance（ for instance, ATP） releasing. This review gives a detailed introduction to the main distribution of Panxl, summarizes the open and inhibition condition of Panxl, and finally, prospects directions of future research.
作者 孔祥兴 李彬寅 管晓静 夏强
机构地区 浙江大学医学院临床医学系 浙江大学医学院附属第二医院心血管内科 浙江大学医学院生理系
出处 《生理科学进展》 CAS CSCD 北大核心 2013年第3期188-192,共5页 Progress in Physiological Sciences
基金 理科基地研究基金(J1103603)资助课题
关键词 Panx1蛋白 分布 调控 Panxl protein distribution regulation
分类号 R34 [医药卫生—基础医学]
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参考文献29

  • 1Panchin Y, Kelmanson I, Matz M, et al. A ubiquitous family of putative gap junction molecules. Current Biology, 2000, 10 : R473 - R474.
  • 2Dvoriantchikova G, Ivanov D, Panchin Y, et al. Expression of pannexin family of proteins in the retina. FEBS Letters, 2006,580 : 2178 -2182.
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二级参考文献27

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生理科学进展
2013年 第3期

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