视黄醇结合蛋白4与老年2型糖尿病视网膜病变的相关性研究

The correlative study of serum retinol-binding protein 4 and diabetic retinopathy of elderly type 2 diabetic patient

目的:探讨视黄醇结合蛋白4(RBP4)与老年2型糖尿病视网膜病变(DR)发生的相关性。方法:选择60岁及以上2型糖尿病患者210例,其中不伴视网膜病变的2型糖尿病108例为对照组(T2DM组),102例视网膜病变的患者为观察组(DR组)。根据眼底病变程度将DR组分为非增殖期组69例(NPDR组)和增殖期组33例(PDR组),分别比较T2DM组与DR组、NPDR组与PDR组的临床参数及生化指标,进一步行logistic回归分析以明确DR的独立危险因素。结果:与T2DM组比较,DR组的病程明显延长,空腹血糖、糖化血红蛋白(HbA1C)及RBP4水平明显增高(P<0.01)。与NPDR组比较,DR组的病程延长,空腹血糖、HbA1C及RBP4水平亦增高(P<0.05)。logistic回归分析示糖尿病病程、HbA1C、RBP4均为DR的独立危险因素(P<0.01)。结论:糖尿病病程、HbA1C、RBP4均为DR发生的危险因素。

Objective：To investigate the correlation of serum retinol-binding protein 4 （RBP4） and diabetic retinopathy （DR） of elderly type 2 diabetic patients. Methods： Two hundred and ten patients, who were 60 years or elder, with type 2 diabetes were investigated, 102 cases without DR and 108 cases with DR were divided into the control and observation group（ namely T2DM and DR group） ,respectively. According to the degree of fundus lesions, DR group were subdivided into non-proliferative stage group（ NPDR group,69 cases） and proliferative stage group（PDR group,33 cases）. The clinical parameters and biochemical indicators of T2DM ＆ DR group and NPDR ＆ PDR group were compared. The independent risk factors of DR were analysed by logistic regression. Results： Compared with the T2DM and NPDR group,the disease course, the levels of fasting blood glucose, HbAlc and RBP4 of DR group prolonged and increased significantly（P 〈 0.01 and P 〈 0.05 ）. The results of logistic regression showed that the disease course, the levels of HbA1 c and RBP4 were independent risk factors of DR（ P 〈 O. 01 ）. Conclusious： The disease course of diabetes, HbA1 c and RBP are three independent risk factors of DR.