产碳青霉烯酶肺炎克雷伯菌感染82例药物治疗分析

The drug analysis of 82 cases infected by Klebsiella pneumoniae carbapenemase-producing Klebsiella pneumoniae strains

目的:探讨我院产碳青霉烯酶(KPC)肺炎克雷伯菌感染患者的确切死亡率、常见危险因素与药物治疗之间的关系。方法:借助电子医疗记录,通过图表,回顾性分析82例产KPC细菌感染的患者(重复检出的患者只记录1次)的临床信息。结果:82例患者中,66例样本产KPC同时产超广谱β内酰胺酶(ESBL),16例样本单产KPC,病死率分别为30例(45.5%)和5例(31.3%),差异无统计学意义(P>0.05)。Cox回归分析:KPC菌株产ESBL使用硫酸多黏菌素B治疗有明显的影响(P<0.01)。结论:使用硫酸多黏菌素B治疗产ESBL患者有一定的效果。

Objective：To explore the relationship between the exact mortality, common risk factors and medication data of the patients infected by Klebsiella pneumoniae carbapenemase （KPC） production strains in this region. Methods：With the help of electric medical record and the chart, the clinical data of 82 cases infected by KPC-producing strains in department of microbiology in our hospital were analyzed retrospectively. Results ：Among these 82 patients ,66 cases were infected by KPC/ESBL co-producing isolates, 16 cases were infected by KPC producing isolates only. The mortality was 30 cases（45.5% ） and 5 cases（31.3% ） respectively,and there was no statistical significance （P 〉 O. 05 ）. In Cox regression analysis, treatment with sulfuric acid polymyxin B had obvious effect（ P 〈 0.01 ）. Conclusions：The treatment with sulfuric acid polymyxin B had certain herapeutic effect on patients infected by KPC-producing strains.