10000例宫颈液基细胞学结果分析

An analysis on the results of thinprep liquid based cytological test in 10 000 patients

目的对2011年我院10000例宫颈液基细胞学（TCT）的检测结果进行分析，并将TCT与组织病理结果进行对比，评价TCT在宫颈病变诊断中的价值。方法对10000例TCT标本应用TBS分级系统进行分析，其中诊断意义不明的不典型鳞状上皮细胞（ASCUS）及以上病变定义为阳性，对其中行活检的患者，以病理结果为金标准，将TCT结果与病理活检结果进行对比分析。结果10000例受检标本中，不合格标本8例（0．8％。），阳性结果为561例（5．61％），其中ASC—H18例，ASCUS333例，LSIL164例，HSIL44例，癌1例，AGC—N1例。宫颈细胞学异常高发人群集中在20—50岁，其中ASCUS和LSIL主要发生在20～40岁，ASC—H和HSIL主要集中在30—50岁。与病理活检结果对比，LSIL符合率为71．6％，HSIL符合率为77．8％。结论宫颈上皮病变有年轻化的趋势，TCT诊断和活检结果符合率较高，TCT是宫颈上皮内病变筛查的最为重要的手段之一。

Objective By analying 10 000 thinprep liquid based cytological test （TCT） results, we assessed the value of TCT in the diagnosis of cervical disease; and then we explored the rate of concordance between positive cervical cytological interpretation based on liquid-based preparations and subsequent histological diagnosis. Methods The diagnosis of 10 000 patients was made according to the criteria of Bethesda system （TBS）, and then compared with the TCT results and the histological diagnosis in the patients with positive results. Results Of the 10 000 patients, 561 （5.61%） were abnormal including 18 ASC-H,333 ASCUS, 164 LSIL, 44 HSIL, one cancer, and one AGC - N. The high-risk of cervical cytology focused on twenty to fifty years, with ASCUS and LSIL mainly in the twenty -years old, ASC - H and HSIL mainly concentrated in the thirty to fifty years old. By comparing with histological diagnosis, LSIL coincidence rate was 71.6% and HSIL was 77.8%. Conclusions Cervical epithelial lesions have a trend in younger people. TCT has a high agreement with biopsy in positive rate, which suggests that TCT has certain predicative value for pathological results.