乌司他丁对重度冠心病心力衰竭患者的影响

Effect of ulinastatin in heavy heart failure patients with coronary heart disease

目的观察乌司他丁对重度冠心病心力衰竭患者的影响。方法选择82例重度冠心病慢性心衰患者（NYHA分级Ⅲ-Ⅳ级）随机分成治疗组（42例）与对照组（40例）。所有患者均常规使用利尿剂、血管紧张素转化酶抑制剂等治疗，治疗组静滴乌司他丁10万U／d，1次，d，7天后观察患者心功能以及CRP、NT—proBNP水平和左室射血分数的变化。结果治疗后，治疗组有效率95．2％，较对照组85．0％有明显提高，两组患者CRP和NT—proBNP水平均有所下降，治疗组下降较为明显，且差异有统计学意义（P〈0．01），左室射血分数有所提高，临床心功能均有改善。结论在常规治疗的基础上加用乌司他丁，能够显著地减轻炎症反应和改善患者的心功能。

Objective To investigate the therapeutic effect of ulinastatin in treatment for heavy heart failure patients with coronary heart disease （CHD）. Methods Eighty-two patients with heavy heart failure （ NYHA ratings Ⅲ-Ⅳ class） and CHD were randomly divided into two groups, all patients used diuretic, angiotensin converting enzyme, etc. And test group was given intravenous drip with ulinastatin for 7 days. The CRP, NT- proBNP and the left ventricular ejection fraction （EF） changes were observed. Results After treatment, CRP and NT- proBNP could be reduced, the clinical heart function of the patients in the two groups was improved; the left ventricular EF of patients in the test group was higher than that in the control group. Conclusion Conventional treatment plus ulinastatin could significantly improve the immune condition and reduce the inflammatory reaction in CHF patients.