盐酸纳洛酮与盐酸纳美芬在重型颅脑损伤后迁延性昏迷治疗中的疗效对比

Comparative efficacy of naloxone and nalmefene hydrochloride in treatment of after severe traumatic brain injurywith persistent coma

目的探讨盐酸纳洛酮与盐酸纳美芬治疗重型颅脑损伤后迁延性昏迷的临床疗效。方法将126例重症颅脑损伤患者随机分为两组，对照组63例患者给予盐酸纳洛酮治疗，观察组63例患者给予盐酸纳美芬治疗，比较两组患者生命体征、颅内压、头颅CT变化和远期疗效，治疗期间严密观察有无药物不良反应。结果观察组患者呼吸循环较快恢复稳定，呼吸异常较对照组明显减少俨〈0．05），伤后1周内观察组患者生命体征较快恢复稳定，颅内压及头颅CT改善情况均优于对照组（P〈0．05）；观察组GCS评分和GOS评分均明显优于对照组（P〈0．05）。结论盐酸纳美芬治疗重型颅脑损伤更安全、更有效、值得临床推广。

Objective To discuss the clinical efficacy of the Naloxone and nalmefene hydrochloride in treatment of after severe traumatic brain injury with persistent coma. Methods 126 patients with after severe traumatic brain injury with persistent coma were randomly divided into two groups, 63 cases in the control group were treated by the Naloxone, and 63 cases in the observation group were treated by the nalmefene hydrochloride, the vital signs, intracranial pressure, CT changes and long-term efficacy of the two groups were compared, and the adverse drug reactions was closely observed during the treatment. Results The respiration and circulation of the observation group was faster to restore stability, the breathing abnormalities was significantly reduced compared with the control group（P 〈 0.05）, after one week, the patients ＇ Vital Signs of the observation group was faster to restore stability, and the Intracranial pressure and cranial CT were improve more than the control group（P 〈 0.05）. The GCS score and GOS score of the observation group were significantly better than the control group （P 〈 0.05）. Conclusion The nalmefene hydrochloride in the treatment of the after severe traumatic brain injury with persistent coma is safe, more effective, and worthy of promotion.