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EBI3在其异源二聚体免疫反应中的作用 被引量：1

Function of EBI3 in the immune response of its heterodimer
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摘要 EB病毒诱导基因3(Epstein-Barr virus induced gene 3,EBI3)是IL-12家族成员,最初发现于EB病毒感染的B细胞培养上清液,为可溶性细胞因子受体,在体内以同源二聚体、IL-27异源二聚体和IL-35异源二聚体三种形式存在。在免疫应答中,EBI3参与Th1、Th2和Th17细胞的活化与分化,发挥抗感染和抗炎症发生中起着重要的作用。 Epstein-Barr virus （EBV）-induced gene 3 （Ebi3） is a member of the interleukin （IL）-12 heterodimeric cytokine family, which was initially discovered as an EBV-induced eellular gene in infected human B lymphoeytes. It associates as a homodimer or a heterodimer with either p28 to yield IL-27 ,or with p35 to form the recently described IL-35. EBI3 is involved in Thl ,Th2 and Thl7 responses and plays a very importent role.
作者 李婧瑶 范礼斌
机构地区 安徽医科大学生命科学学院
出处 《安徽医药》 CAS 2013年第1期135-137,共3页 Anhui Medical and Pharmaceutical Journal
关键词 EBI3 IL-27 IL-35 作用 EBI3 IL-27 IL-35 function
分类号 R392 [医药卫生—免疫学]
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参考文献24

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安徽医药
2013年 第1期

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