沙棘干乳剂防治阿奇霉素静脉滴注致胃肠道不良反应临床观察

Clinical observation of seabuckthorn dry emulsion to prevent gastrointestinal adverse reaction induced by intravenous infusion of azithromycin

目的观察沙棘干乳剂对静脉滴注阿奇霉素所致胃肠道不良反应的防治效果。方法将130例采用静脉滴注阿奇霉素治疗的呼吸道感染患儿随机分为观察组和对照组各65例,对照组应用维生素B6静脉入壶,观察组在静脉滴注阿奇霉素前30 min口服沙棘干乳剂。比较2组患儿消化道不良反应的发生情况。结果对照组患儿胃肠道无反应率为32.3%,观察组无反应率为58.5%,2组比较,观察组显著高于对照组(P<0.01)。此外,观察组患儿轻、重度胃肠道不良反应发生率分别为36.9%,4.6%,显著低于对照组(P<0.05)。结论沙棘干乳剂用于防治静脉滴注阿奇霉素所致胃肠道不良反应疗效确切,且服用方便,患儿易于接受。

Objective To observe prevention and treatment effect of seabuckthorn dry emulsion on gastrointes- tinal adverse reaction caused by intravenous infusion of azithromyein. Methods 130 cases of respiratory tract in- fection treated with intravenous azithromyein were randomized into the observation group and control group, 65 ca- ses in each group. Control group used vitamin B6 intravenously. Observation group took seabuckthorn dry emulsion 30 rain before intravenous azithromycin. Compare the 2 groups of gastrointestinal adverse reactions. Results The gastrointestinal non-response rate was 32.3% in the control group, 58.5% in the observation group, with observa- tion group significantly higher than control group （ P〈0.01 ）. In addition, mild, severe gastrointestinal adverse re- action rates were 36.9% , 4.6% in observation group, which were significantly lower than that in control group （P〈0.05 ）. Conclusion Seabuckthorn dry emulsion can be used for prevention and treatment of gastrointestinal adverse reaction induced by intravenous azithromycin with curative effect, convenient use and easy to be accepted.