益生菌在溃疡性结肠炎治疗中的疗效及机制探讨

Curative effect and mechanism of probiotics in the treatment of ulcerative colitis

目的探讨益生菌在溃疡性结肠炎(UC)治疗中的疗效及可能机制。方法将94例UC患者随机分为对照组和观察组各47例,对照组给予美沙拉嗪治疗,观察组在对照组基础上联合给予益生菌治疗,对比两组的治疗结果。结果观察组综合疗效总有效率93.62%优于对照组的72.34%,复发率6.82%低于对照组的26.47%。观察组治疗后血清CRP、Baron内镜下活动度、HNP1-3表达水平、DAI等观察指标均较对照组改善更为显著,差异均有统计学意义(P<0.05);两组安全性类似,差异无统计学意义(P>0.05)。结论益生菌可多机制协同诱导UC缓解,减少复发,临床治疗中建议选择使用。

Objective To study the efficacy and possible mechanism of probiotics in the treatment of ulcerative colitis （UC）. Methods Ninety-four cases of patients with UC were divided into control group and observation group,47 cas- es in each group.Patients in control group were treated by mesalazine ,while the observation group were treated by pro- biotics on the basis of mesalazine, the efficacy of the two groups were compared. Results The total effective rate of ob- servation group （93.62%） was superior to control group （72.34%）,the recurrence rate of observation group （6.82%） was lower than the control group （26.47%）,the serum levels of CRP,Baron endoscopic activity, expression level of HNP1-3 and DAI of observation group were significantly improved more than that of control group（P 〈 0.05）; security was similar in both groups,there was no statistically significant difference between the two groups （P 〉 0.05）. Conclusion Probiotics can alleviate UC by multiple cooperating mechanism and reduce the recurrence, so it＇s suggested to choose in the clinical treatment.