昂丹司琼不同时间及不同剂量给药在预防妇科腹腔镜手术PONV的临床效果

Clinical efficacy of ondansetron with different time and different doses in preventing PONV of gynecological laparoscopic operation

目的探讨昂丹司琼不同时间及不同剂量给药预防妇科腹腔镜手术术后恶心呕吐的临床效果。方法选择全麻下行妇科腔镜手术的患者100例为研究对象,分为四组,每组25例。第一组在麻醉诱导前5 min昂丹司琼8 mg静脉注射;第二组手术结束时昂丹司琼8 mg静脉注射;第三组麻醉诱导前5 min昂丹司琼4 mg静脉注射;第四组整个麻醉期间未使用任何抗呕吐药物。比较四组术后24 h内恶心呕吐的发生率及程度。结果第一组、第二组、第三组无效例数显著低于第四组,差异均有统计学意义(P<0.05)。结论昂丹司琼能有效降低术后恶心呕吐的发生率,且临床效果与不同时间和不同剂量无明显关系。

Objective To discuss clinical efficacy of ondansetron witn different time and different doses in preventing PONV of gynecological laparoscopic operation. Methods Selected 100 cases with gynecological laparoscopic operation, were divided into four groups. The first group 8 mg ondansetron was injected 5 min before anesthesia induction. The second group 8 mg ondansetron was injected after operation. The third group 4rag ondansetron was injected 5 min be- fore anesthesia induction. The forth group didn＇t given any anti-vomiting drugs. PONV was compared in four groups during 24 h after operation. Results Invalid cases of the irst group, the second group and the third group were apparently less than the forth group, with statistical significance （P 〈 0.05）. Conclusion Ondansetron can reduce PONV af- ter operation. And clinical efficacy has nothing to do with time and doses.