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PTHrP-Ihh信号轴对软骨内成骨的调控作用 被引量：4

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摘要 长骨的生长主要经过软骨内成骨和膜内成骨。软骨内成骨即长骨干骺端生长板的发育过程,生长板软骨细胞从静止期到增殖期再到肥大期及钙化期的排列、增殖、分化、矿化、血管化等一系列过程调节着长骨的生长。生长板软骨细胞的分化和成熟的过程受全身或者局部多种激素,细胞因子的调控。其中印第安刺猬蛋白(Indian hedgehog,Ihh)与甲状旁腺激素相关肽(Parathyroid hormone-related peptide,PTHrP)所形成的信号系统在骨骼生长板中软骨细胞的增殖、分化、肥大、凋亡及软骨基质钙化过程中,具有重要的调控作用。
作者 马荣生 周振雷 侯加法
机构地区 南京农业大学动物医学院
出处 《畜牧与兽医》 北大核心 2013年第7期96-99,共4页 Animal Husbandry & Veterinary Medicine
基金 江苏省自然科学基金(BK2011648)
关键词 甲状旁腺激素相关肽 PTHRP IHH 软骨内成骨
分类号 S852.2 [农业科学—基础兽医学]
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参考文献20

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二级参考文献26

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共引文献6

同被引文献54

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二级引证文献9

畜牧与兽医
2013年 第7期

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