溃疡性结肠炎合并肿瘤性息肉的危险因素分析

Relative Analysis of Ulcerative Colitis Associated with Neoplastic Polyps

目的:探讨溃疡性结肠炎合并肿瘤性息肉的流行病学、发病机制的特点以及危险因素。方法:选择我院2008年6月至2012年3月收治的25例溃疡性结肠炎合并肿瘤性息肉(观察组)、25例散发性肿瘤性息肉(对照一组),25例大肠息肉癌变患者为研究对象(对照二组)的临床资料进行回顾性分析,对各组患者息肉标本及临床危险因素进行分析。结果:观察组结肠镜下形态学特点、组织学分型与对照一组存在显著性统计学差异(P<0.05),而与对照二组患者无统计学差异(P>0.05)。观察组与对照一组的临床危险因素比较,其中性别、年龄、BMI指数、病理分型、息肉直径大小、P53阳性和其他因素(有原发性硬化性胆管炎、结直肠癌家族史)存在统计学差异,与对照二组危险因素仅有性别存在统计学差异。结论:溃疡性结肠炎合并肿瘤性息肉患者在病理组织类型特点与危险因素与息肉癌变者更为相近,临床诊断治疗过程中应给予高度重视。

Objective： To explore the epidemiology, pathogenesis and risk factors of ulcerative colitis associated with neoplastic polyps. Methods： 25 cases of ulcerative colitis with neoplastic polyps （observation group）, 25 cases of sporadic neoplastic polyps（control group I ）, 25 cases of colorectal polyps （control group II ） hospitalized in our hospital from June 2008 to March 2012 were retrospectively studied. Polyps specimens and clinical risk factors of each group were analyzed. Results： Significant statistical differences of colonoscopy morphological and histological type features between observation group and control group I had been found（P〈0.05）, but no significant difference was found between observation group and control group II had been found （P〉0.05）. Comparing the observation group with control group I , gender, age, BMI index, type of histology, diameter number, positive of P53, others mean related clinical factors, such as primary sclerosing cholangitis and family history of colorectal carcinoma were statistically significant clinical risk factors, while comparing the observation group with control group II, only gender was statistically significant clinical risk factor. Conclusion： Ulcerative colitis associated with neoplastic polyps patients characteristics of histopathological types, risk factors were more similar to polyps canceration, clinical diagnosis and treatment should be given high priority.