摘要
目的:探讨地特胰岛素联合门冬胰岛素与生物合成人胰岛素注射液R对2型糖尿病强化治疗的疗效。方法:回顾性分析近年来我院住院治疗的180例2型糖尿病患者的临床资料,随机分为两组,每组90例,观察组予门冬胰岛素联合地特胰岛素治疗,对照组予生物合成人胰岛素注射液R治疗,记录并分析两组治疗前后空腹血糖(FPG)、餐后2小时血糖(2h-PPG)、血糖达标时间、达标时胰岛素用量及低血糖发生情况。结果:观察组较对照组患者在治疗前后糖化血红蛋白值、空腹血糖值都有所降低,血糖达标时间(d),胰岛素日用量(U/kg*d)及低血糖发生率(次/人)都有所减少,疗前后Homa-IR有所降低,Homa-β及体重有所增加,两组患者在治疗后糖尿病并发症都有所好转,观察组较对照组改善情况更优,但无显著性差异;其中对照组较观察组在糖化血红蛋白值、空腹血糖值上的比较中无显著差异。结论:门冬胰岛素联合地特胰岛素较生物合成人胰岛素注射液R强化治疗2型糖尿病患者与疗效接近,但起效迅速,持续时间久,低血糖反应少,胰岛素用量低。
Objective： To investigate the effects of detemir combined with insulin aspart with biosynthetic human insulin injection R effect of intensive treatment of type 2 diabetes.Methods： A retrospective analysis of the clinical data in recent years,our hospital 180 patients with type 2 diabetes were randomly divided into two groups,with 90 cases in each group： the observation group to insulin aspart joint detemir treatment,and control group to the biosynthesis treatment of human insulin injection R.Before and after treatment,fasting plasma glucose（FPG） and 2-hour postprandial blood glucose（2h-PPG）,blood glucose time when the standard dosage of insulin and hypoglycemia happens were recorded and analyzed.Results： Compared with the control group,glycosylated hemoglobin values,fasting blood glucose levels,blood glucose time（d）,insulin daily dose（U/kg＊d） and the incidence of hypoglycemia hasreduction of patients in observation group are reduced after treatment,and Homa-IR decreased,Homa-β and weight increase after treatment.Diabetic complications of patients in two groups in has improved,the situation in the observation group is better than the control group,but there was no significant difference.Furthermore,hemoglobin and fasting glucose values was no significant between two groups.Conclusion： The effect of the insulin aspart joint detemir is close to biosynthetic human insulin injection R intensive therapy,but the former is rapid,long duration,low blood sugar reactions,low dosage.
出处
《现代生物医学进展》
CAS
2013年第21期4159-4162,共4页
Progress in Modern Biomedicine
