CK4基因在喉咽鳞癌中的表达及意义(英文)

The Study of CK4 Expression and Significance in the Hypopharyngeal Squamous Cell Carcinomas

目的:探讨喉咽鳞癌组织中细胞角蛋白4(CK4)的表达及其临床意义。方法:应用免疫组织化学方法检测60例喉咽鳞癌患者的癌旁正常组织和癌组织标本中CK4的表达。结果:CK4在癌旁正常组织中表达强阳性,在喉咽鳞癌组织中表达下降,其差异有统计学意义(x2=73.594,P<0.05)。与高分化鳞癌相比,CK4在中分化和低分化鳞癌组织中表达均出现明显下降,其差异有统计学意义(F=57.082,P<0.05)。结论:CK4在喉咽鳞癌组织中的低表达对喉咽鳞癌的诊断有一定的临床意义,并有望成为喉咽鳞癌恶性程度的生物学标记物。

Objective： To investigate the expression and clinical significance of the cytokeratin 4 in hypopharyngeal squamous cell carcinomas.Methods： The expression of CK4 was detected by immunohistochemistry approach in normal tissue of latero-carcinoma and tissue of carcinoma in 60 species of hypopharyngeal squamous.Results： The expression of CK4 was strong positive in the normal tissue of latero-carcinoma,while CK4 expression reduced in the hypopharynx squamous carcinoma tissue.The variance was statistical significance（x 2 =73.594,P0.05）.Compared with that in the high differentiated squamous cell carcinoma,the expression of CK4 in moderately differentiation and poorly differentiated squamous carcinoma tissue all appear declined obviously.The variance was statistical significance（F=57.082,P0.05）.Conclusion： CK4 has low expression in hypopharynx squamous carcinoma.It has certain clinical significance in the diagnosis of hypopharynx squamous carcinoma,and CK4 is expected to become the biological marker of hypopharynx squamous carcinoma malignant degree.