摘要
目的 探讨男性慢性肾衰患者血清性激素水平的变化及临床意义。方法 采用磁性分离匀相酶联免疫测定法 ,测定 30例慢性肾衰者 ,31例慢性肾炎者 ,5 0例健康体检者性激素水平进行统计分析。结果 男性慢性肾衰组血清孕酮 (P)、泌乳素 (PRL)、黄体生成素 (L H)较对照组及慢性肾炎组显著增高 (P <0 .0 1或 P <0 .0 5 ) ,血清睾酮 (T)水平、T/ P和 FSH/ L H比值显著降低 (P<0 .0 1) ,血清 P、PRL、T/ P与血肌酐水平相关 ,慢性肾炎组性激素水平与对照组比较 E2 明显升高 (P <0 .0 5 ) ,余差异不明显。结论 男性慢性肾衰患者性激素比例严重失调是性功能障碍的重要原因之一 ,血清 PRL、P、T/
Objective To study the change of levels of serum sex hormone and its clinical significance in male patients with chronic renal failure (CRF).Methods The levels of serum sex hormones were detected by ELISA in 30 cases of CRF, 31 cases of chronic glomerulonephritis,and 50 cases of control group.Results Compared with those in the control group and chronic glomerulonephritis,the average levels of progesterone (P),prolactin (PRL) and luteinizing hormone (LH) in patients with CRF were significantly higher (P<0.01 or P <0.05) .Furthermore,the average level of testosterone (T) and the ratio of T/P,FSH/LH in patients with CRF were markedly lower (P<0.01).There was correlation between the levels of P,PRL and T/P ratio with the elevation of plasma creatinine respectively.The average level of estradiol (E) in patients with chronic glomerulonephritis was much higher than that in the controls (P<0.05).Conclusion The imbalance of proportions between serum E and T,P and T,FSH and LH is one of the important reasons for sex dysfunction.The average levels of PRL,P and T/P ratio are of reference values in judging the severity of renal failure.
