水生生物谷胱甘肽相关酶对持久性有毒物质响应机理的研究

Research on Glutathione Related Enzyme ’s Response to Persistent Toxic Substances in Aquatic Organisms

谷胱甘肽酶类作为生物体内重要的Ⅱ相解毒酶类和抗氧化酶类的重要组成部分,在持久性有毒物质的生物代谢中具有重要作用。主要介绍水生生物体内谷胱甘肽硫转移酶和谷胱甘肽过氧化物酶对有机污染物和重金属的解毒效应及其在分子生物学方面的研究成果,并对其在环境监测和污染诊断方面的应用前景以及今后的研究方向进行展望。

Glutathione related enzymes, which are the phase II detoxification enzymes and antioxidant enzymes in vivo, have an important role in biological metabolism of persistent toxic substances. In this paper the detoxification effect of glutathione S-transferase and glutathione peroxidase on organic pollutants and heavy metals, and molecular research in these two enzymes are briefly discribed. The results of these researchs will provide us insight in the future applications of glutathione related enzymes in environmental monitoring and pollution diagnosis.