微乳液法制备庆大霉素多孔羟基磷灰石微球

Study on the preparation of gentamicin porous hydroxyapatite microspheres by the method of emulsion

目的:采用微乳液法制备羟基磷灰石-明胶微球,再经高温去除明胶,得到多孔羟基磷灰石微球,并对药物的控释性能进行研究。方法:通过X线衍射,扫描电子显微镜等手段对制备的多孔羟基磷灰石微球进行表征,并以庆大霉素为模型药物,考察其释药性能。结果:制备的羟基磷灰石微球呈多孔状,直径为900μm左右。对庆大霉素的载药量能达到17%,包封率能达到47%,持续释药时间能够达到10 d。结论:采用微乳液法制备的多孔羟基磷灰石微球对药物具有很好缓释作用。

OBJECTIVE To prepare hydroxyapatite/gelatin microspheres was prepared by the method of emulsion, then the porous hydroxyapatite microspheres were fabricated after the gelatin was eliminated from the composite microsphere through sintering, and the controlled release performance in vitro was investigated in this paper. METHODS The scanning electron mi- croscopy （SEM） and X-ray diffraction （XRD） were utilized to characterize the prepared porous hydroxyapatite microspheres. And the gentamicin sulfate was chosen as the model drug to investigate the drug release property of the microspheres. RESULTS The prepared microspheres possessed porous structures and had an average diameter of 900μm or so. The drug loading effi- ciency and entrapment efficiency of the gentamicin porous hydroxyapatite microspheres were above 47% and 17%, respective- ly. The release capacity of the prepared gentamicin sulfate porous hydroxyapatite microspheres was about 10 days. CONCLU- SION Porous hydroxyapatite microspheres as drug delivery vehicle has favorable drug release behavior in vitro.