肝移植5年后生存影响因素分析

Factors affect survival 5 years after liver transplantation

目的评估我院肝移植患者长期生存情况,分析肝移植5年后生存质量的影响因素。方法回顾性分析2000年3月至2007年8月完成46例生存超过5年的肝移植病例,分析死亡原因、各种并发症情况。结果生存超过5年的46例患者中,死亡4例,其中胆道并发症2例,重症乙型肝炎1例,心肌梗塞1例,各种并发症:高脂血症8例,高血压7例,糖尿病3例,胆道并发症6例,乙肝复发3例,肾功能损害2例,心肌梗塞1例。结论胆道并发症、乙肝复发及免疫抑制剂副作用是影响肝移植5年后生存质量的主要因素,加强多学科长期临床随访指导,低剂量免疫抑制剂联合应用是提高肝移植5年后生存质量的重要因素。

Objective To evaluate long-term survival of patients with liver transplantation, analysis of the factors that affect the liver transplant five years survival. Methods A retrospective analysis of 46 patients survived more than five years of cases of liver transplantation from March 2000 to August 2007, analysis the cause of death and complications. Results 46 patients survive more than 5 years, 4 patients died, including two cases of biliary complications, one case of severe hepatitis B, and one case of myocardial infarction. Complications ： high blood pressure（ n = 7 ） , diabetes（ n = 3 ） , biliary complications （ n = 6 ） , hepatitis B recurrence （ n = 3 ）, renal dysfunction （n = 2 ）, and myocardial infarction （n = 1 ）. Conclusion Biliary complications, hepatitis B recurrence and side effects of immunosuppressants that affect long-term survival after liver transplantation 5 years, strengthen multidisciplinary long- term clinical follow-up guidance, the combination use of low-dose immunosuppressant are important factors to improve the quality of life 5 years after liver transplantation.