低密度脂蛋白受体相关蛋白1B在大肠癌中的表达及意义

Expression of low density lipprotein receptor-related protein 1B in tissues of colorectal carcinoma and its clinical pathological significance

目的研究低密度脂蛋白受体相关蛋白1B基因(LRP1B)在大肠癌中的表达情况,同时探讨其在大肠癌中发生进展中的作用。方法采用原位杂交的检测方法,用LRP1B寡核苷酸作探针,对55例大肠癌组织及15例癌旁正常组织标本中LRP1B mRNA的表达进行测定。结果①在55例大肠癌标本中,有16例LRP1B表达阳性,阳性率为29.10%。15例正常大肠对照组中,有13例LRP1B表达阳性,阳性率为86.67%。两组之间差异有显著性(P<0.01)。②LRP1B在大肠癌中的表达与患者的年龄、性别、淋巴结浸润和远处转移无明显相关性(P>0.05),与肿瘤的浸润深度、肿瘤大小及病理学分期呈负相关(P<0.05)。结论 LRP1B在大肠癌组织中的表达下调或缺失对大肠癌的预后判断有一定的参考价值。

【Objective】 To investigate the expression of Low density lipprotein receptor-related protein 1B（LRP1B） in colorectal carcinoma and relationship with pathological clinical features,then explore the possible effect in the development of colorectal carcinoma.【Methods】In situ hybridization was used to detect the expression of LRP1B in 15 normal colorectal tissues and 55 colorectal carcinoma specimens.【Results】① Of 55 cases of colorectal cancer specimens,16 cases LRP1B expression,the positive rate was 29.10%.15 normal colon control group,13 cases LRP1B expression,the positive rate was 86.67%.The difference between the two groups was significant（P 0.01）.②LRP1B expression in colorectal cancer with age,gender,lymph node invasion and distant metastasis was no significant correlation（P 0.05）,and the depth of tumor invasion,tumor size and pathological stage was negatively correlated（P 0.05）.【Conclusion】The reduction or deletion of LRP1B in colorectal cancer tissue has certain reference value to the prognostic of colorectal cancer.