基底节内囊区梗死后血管性认知功能损害的临床分析

Clinical study on vascular cognitive impairment after infarction of basal ganglia-capsula interna area

目的探讨基底节内囊区梗死后血管性认知功能损害特点。方法以蒙特利尔认知评估量表(MoCA)为评估工具,检测2011年1月至2012年9月住院的42例基底节内囊区梗死患者起病后3个月(病例组)和35例正常者(对照组)的认知功能状态。结果病例组MoCA分值(18.98±4.36)较对照组(23.17±2.26)明显下降,差异有统计学意义(P<0.01)。病例组中25例(59.5%)MoCA<23分。病例组与对照组比较,视空间与执行(2.90±1.28vs3.69±0.83,P<0.01)、注意力(3.45±1.37vs4.80±1.08,P<0.01)、抽象思维能力(0.76±0.69vs1.31±0.63,P<0.01)均明显下降。结论基底节内囊区梗死后患者血管性认知功能损害发生率高,以执行功能﹑注意力及抽象思维能力损害为主要表现。

Objective To investigate the characteristics of vascular cognitive impairment after cerebral infarction in basal ganglia-capsula interna area. Methods Forty-two patients with basal ganglia-capsula interna area infarction three months after onset （case group） who admitted between January 2011 and September 2012,and 35 healthy subjects （control group） were enrolled in present study. The cognitive functions in all participants were evaluated by Montreal Cognitive Assessment （MoCA） . Results The scores of MoCA in case group were significantly lower than that in control group （18.98±4.36 vs 23.17 ±2.26,P0.01） . Of 42 cases in case group,25 （59.5% ） had a MoCA score less than 23. Compared with control group,the scores of view space and executive capability （2.90 ±1.28 vs 3. 69±0. 83,P0. 01） ,attention （3.45±1.37 vs 4.80±1.08,P0.01） and abstract thinking capability （0.76±0.69 vs1.31 ±0.63,P0.01 ） in case group significantly lowered. Conclusions Vascular cognitive function impairment is common in patients with basal ganglia-capsula interna area infarction,and the dysfunctions of view space and executive capability,attention and abstract thinking capability are its main manifestation.