间充质干细胞作为新型纳米靶向抗肿瘤药物载体的研究进展

Progress in mesenchymal stem cells as a novel nano-targeted antitumor drug carrier

近年来，作为药剂学研究热点领域之一的靶向给药系统受到越来越多的关注。然而，这些抗肿瘤靶向载药运输系统存在诸多缺点如靶向效率低等而限制其在临床上的应用，提高肿瘤靶向效率已成为纳米药物研发和临床应用的瓶颈问题。因此，迫切需要设计并开发新型靶向药物递送载体。最近研究表明，间充质干细胞（MSCs）具有肿瘤趋向性和可迁移等特点，这些特点使得它们能够作为理想的抗肿瘤靶向药物递送载体来治疗实体瘤和转移瘤。综述了利用间充质干细胞作为肿瘤治疗的靶向药物递送载体的研究进展，概述了该系统存在的问题和挑战，并提出了针对这些问题的解决方法。

In recent years, targeted drug delivery system as one of the hottest areas in pharmaceutical research has received more and more attention. However, the targeted anti-tumor drug delivery system has many shortcomings including low targeted efficiency which limit its clinical application. Elevating tumor targeting efficiency has become the bottleneck of nano-drug development and clinical application. Therefore, it is urgent to design and develop novel targeted drug delivery vehicle. Recent studies showed that mesenchymal stem cells （MSCs） have characters of tumor tropism and migration, which make them as ideal targeted anti-tumor drug delivery carriers for the treatment of solid and metastatic tumors. This paper reviews the progress in using MSCs as targeted anti-tumor drug delivery carrier, recapitulates the problems and challenges of the system, and proposes a solution for these problems.