用近红外扩散相关谱无创监测肿瘤的光动力治疗

Application of near infrared diffuse correlation spectroscopy in noninvasive monitoring of tumor photodynamic therapy

一种新颖的近红外（NIR）光扩散相关谱（DCS）技术最近被研发出来用于无创检测光动力治疗（PDT）期间的肿瘤血流量变化。DCS为肿瘤血流量测量提供了一些有吸引力的新特征如无创性、可携带性、低成本、高的时间分辨率和相对较大的穿透深度。DCS技术已被用于连续监测PDT引起的人体及动物肿瘤血流量的变化。这些研究的最终目标是利用监测PDT对肿瘤血流动力学的影响来预测和优化治疗效果。

A novel near-infrared （NIR） diffuse correlation spectroscopy （DCS） has recently been developed for noninvasive monitoring of tumor blood flow during photodynamic therapy （PDT）. DCS offers several attractive new features for tumor blood flow measurement such as noninvasiveness, portability, low cost, high temporal resolution and relatively large penetration depth. DCS technology has been utilized for continuous measurement of tumor blood flow before, during and after PDT in both animals and humans. The ultimate goal is to predict treatment outcomes from the measured tumor hemodynamic responses to PDT.