摘要
目的分析病理T2～3N0食管癌临床病理特征对预后的影响。方法回顾性分析422例病理T2～3N0胸段食管癌患者的临床资料，应用Kaplan—Meier法进行单因素生存分析，组间比较用Log—rank检验，多因素生存分析采用Cox模型分析。结果总的1、3和5年生存率分别为89．3％、63．5％、52．5％。单因素生存分析结果显示性别、肿瘤浸润深度和组织分化是影响食管癌预后的因素（x2值分别为7．45、7．79、15．81，均P〈0．01），Cox回归多因素生存分析显示性别、肿瘤浸润深度和组织分化也是食管癌预后的独立影响因素。结论性别、肿瘤浸润深度和组织分化是病理T2～3N0食管癌预后的独立影响因素，外科手术旱病押T2～3N0食管痛的标准治疗方法。
Objective To analyze the clinicopathologic features of patients with pathologic T2～3N0 thoracic esophageal squamous cell carcinoma （ESCC） and correlation to their prognosis. Methods The elinicopathologic data of 422 patients with pathologic T2-3N0 thoracic ESCC, who were treated with surgex3, were analyzed. Cumulative survival rate was analyzed by the Kaplan-Meier method and compared by Log-rank test. Cox regression model was used for multivariate prognostic analysis. Results The overall 1-, 3- and 5- year survival rates were 89.3 %, 63.5 % and 52.5 %, respectively. Univariate analysis revealed that the factors affecting the prognosis included gender （X2 = 7.45, P 〈 0.01）, depth of invasion （X2 = 7.79, P 〈 0.01） and tissues differentiation （X2 = 15.81, P 〈 0.01）. They were also independent prognostic factors according Cox regression multivariate survival analysis. Conclusion The gender, depth of invasion and differentiation should be independent prognostic factors of pathologic T2～3N0 ESCC. Surgery is still the standard treatment for pathologic T2～3N0 esophageal cancer.
出处
《肿瘤研究与临床》
CAS
2013年第6期375-377,381,共4页
Cancer Research and Clinic
关键词
食管肿瘤
外科手术
预后因素
Esophageal neoplasms
Surgical operation
Prognostic factors
