造血干细胞移植研究和应用的回顾与展望

Review and prospects on research and application of hematopoietic stem cell transplantation

结合第54届美国血液学会年会教育论坛的相关内容着重复习造血干细胞移植（HSCT）领域的一些进展。在论述人类白细胞抗原（HLA）配型技术和供者来源扩展的基础上，分别简述了各类HSCT（HLA-相合同胞供者移植、脐带血移植、无关供者移植、HLA-单倍型相合的移植）疗效的提升，也回顾了疾病种类和病期对HSCT结局的影响；结合自身的理解与经验，强调确保供者安全的注意事项与意义。

The outcome of allogeneic hematopoietic stem cell transplantation （allo-HSCT） has been improved over past 50 years due to the advances in HLA matching and increasing sources of HSC donors, such as developments and progressions of HLA-matched sibling donor transplantation （MSDT）, umbilical cord transplantation （UCBT/CBT）, unrelative donor transplantation （URDT）, and HLA haploidentical transplantation （haplo-SCT）. To review and discuss progressions in field of allo-HSCT, we studied relative advances reports of Education Program Book, 54th-ASH, 2012. Howeover, the outcomes of allo-HSCT can be quite different according to different diseases, disease phase or patient age. Furthermore, according to our local experiences, we emphasize again significance of HSCT donor safety.