介入化疗前后宫颈鳞癌组织TS和TP表达及意义

THE EXPRESSIONS OF TS AND TP AND THEIR SIGNIFICANCE IN SQUAMOUS CELL CARCINOMA OF THE CERVIX BEFORE AND AFTER CHEMOTHERAPY

目的探讨肿瘤细胞相关生长因子胸苷酸合酶(TS)和胸苷磷酸化酶(TP)在动脉介入化疗栓塞前后宫颈鳞癌组织中表达的变化及临床意义。方法采用免疫组织化学方法分别检测介入化疗前后40例宫颈鳞癌组织及20例正常宫颈组织中TS、TP表达,并分析介入化疗前后TS、TP表达与临床有效性的关系。结果介入化疗后宫颈鳞癌组织中TS、TP的表达较介入化疗前显著下降(χ2=4.377、7.200,P<0.05);TS、TP在介入化疗前后的表达变化与化疗疗效呈负相关(r=-0.500、-0.449,P<0.05)。结论 TS、TP的表达变化与宫颈鳞癌的发生发展密切相关,对于临床指导治疗以及判断预后有一定的价值。

Objective TQ study the expressions of TS and TP in squamous carcinoma （SC） of the cervix before and after arterial chemoembolization and their clinical significance. Methods Immunohistochemical method was employed to detect the expressions of TS and TP in cancer tissue of 40 patients with SC of the cervix and normal tissue of the cervix in 20 cases, lhe asso clarion of expressions of TS and TP with therapeutic efficacy was analyzed. Results After chemotherapy, the expressions of TS and TP decreased significantly （x2=4.377,7.200;P〈0.05）, which were negatively correlated with the chemotherapeutic efficacy （r=-0.500, -0.449;P〈0.05）. Conclusion he changes of TS and TP expression are closely related with the occurrence of SC of the cervix, which is of a certain value in guiding therapy and predicting prognosis of this malignancy.