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丹红对ST段抬高型急性心肌梗死PCI术后心肌无复流影响及其机制 被引量:9

EFFECT OF DAN-HONG ON MYOCARDIAL NO-REFLOW AFTER PERCUTANEOUS CORONARY INTERVENTION IN PATIENTS WITH ST ELEVATION MYOCARDIAL INFACTION AND ITS MECHANISM
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摘要 目的探讨丹红对ST段抬高型急性心肌梗死经皮冠状动脉介入(PCI)术后无复流现象的影响及其可能机制。方法 ST段抬高型急性心肌梗死病人60例,随机分成PCI+丹红组(丹红组)和直接行PCI组(直接PCI组),各30例。丹红组PCI手术开始即给予丹红注射液4 mL稀释后静脉缓慢注射,然后给予丹红注射液20mL稀释后静脉滴注,维持至PCI手术结束;直接PCI组不用丹红。应用单导联ST段回落百分比、矫正的冠状动脉血流分级(TIMI)帧数计数来评估心肌再灌注情况,同时监测术前术后病人炎症因子白细胞介素-6(IL-6)的变化。结果丹红组矫正的TIMI帧数>40s的病例数显著少于直接PCI组(χ2=6.405,P<0.05),PCI术后单导联ST段回落良好(≥50%)病人例数多于直接PCI组(χ2=4.593,P<0.05);IL-6回落水平大于直接PCI组(t=2.058,P<0.05)。结论丹红可减少ST段抬高型心肌梗死PCI术后无复流现象的发生率,其机制可能是通过抑制IL-6的释放发生作用。 Objective To study the effect of Dan-hong on no-reflow phenomenon in patients with ST elevation acute my- ocardial infarction (AMI) after percutaneous coronary intervention (PCI) and its possible mechanism. Methods Sixty patients with ST elevation AMI were evenly randomized to PCI^-Dan-hong group (Dan-hong group) and PCI group. The patients in Dan- hong group were given intravenous Dan-hong injections 4 mL (to be diluted) at the beginning of PCI, and then 20 mL for intrave- nous drip, which was kept until the end of the procedure; for those in PCI group, PCI was performed only, without Dan-hong. Resolution of the single ST segment elevation (STR≥50%) after PCI, corrected TIMI frame count (CTFC) and the level of inter- leukin-6 (IL-6) after PCI were used to evaluate the degree of no-reflow. Results The CTFC (frame number 〉40 s) of Dan- hong group was significantly less than PCI group (X2 = 6. 405, P d0.05). The STR (〉 50%) after PCI in Dan-hong group was higher than that in PCI group (Zz =4.593 ,P〈0.05). There were significant differences between Dan-hong group and PCI group on STR. The serum levels of IL-6 after PCI in PCI group were higher than the Dan-hong group (t =2.058,P〈0.05). Conclusion Dan-hong can reduce no reflow phenomenon in patients with AMI. The mechanism may be that through inhibiting the release of IL- 6 and thus reduce the occurrence of no reflow.
出处 《齐鲁医学杂志》 2013年第3期250-252,共3页 Medical Journal of Qilu
基金 青岛市科技发展指导计划(KZD-12)
关键词 心肌梗死 血管成形术 经腔 经皮冠状动脉 丹红注射液 白细胞介素-6 myocardial infarction angioplasty, transluminal, percutaneous coronary Dan-hong interleukin-6
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参考文献10

  • 1KIERNANT J, RUGGIERON J, BERNAL J M, et al. The no reflow phenomenon: a basic mechanism of myocardial [J]. Cardiovascular & Hematological Agents in Medicinal Chemistry, 2009(7): 181-192.
  • 2THORSTEN R A. Kloner ischemia and reperfusion[J]. Basic Res Cardiol, 2006,101:359-372.
  • 3GIBSON C M, CANNON C P, DALEY W L, et al. TIMI frame count: a quantitative method of assessing coronary artery flow[J]. Circulation, 1996,93(5) :879-888.
  • 4周晓彬,张健.医学统计软件系统PPMS 1.5的应用举例[J].齐鲁医学杂志,2011,26(6):502-505. 被引量:124
  • 5ANTMAN E P. ACC/AHA guidelines for the management of patients with ST elevation myocardial infarction[-J-. Circulation, 2004,110(9):588-636.
  • 6SYEDMA, BORZAKS, ASFOURA, et al. Single lead ST- segment recovery: a simple, reliable measure of successful fi brinolysis after acute myocardial infarction [J]. American Heart Journal, 2004,147(2):275-280.
  • 7BAINEY K R, SENARATNE M P. Is the outcomes of early ST-segment resolution after thrombolytic therapy in acute my- ocardial infarction always favorable[J]. Journal of Electrocar- diology, 2005,38 (4) : 354-360.
  • 8李明哲,赵利华.白细胞介素-6水平在急性心肌梗死再灌注冠脉介入治疗过程中的变化[J].中国现代医生,2011,49(25):67-69. 被引量:1
  • 9ENGLER R L, SCHMID-SCHONBEIN G W, PAVELEC R S. Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog[J]. The American Journal of Pathology, 1983,111(1):98-111.
  • 10PUDIL R, PIDRMAN V, KREJSEK J, et al. Cytokines and adhesion molecules in the course of acute myocardial infarction [J]. Clinica Chimica acta; International Journal of Clinical Chemistry, 1999,280(1-2): 127-134.

二级参考文献15

  • 1Stone GW, Brodie BR, Griffin JJ, et al. A prospective, multicenter study of the safety and feasibility of primary stenting in acute myocardial infarction : inhospital and 30 day results of the PAMI Stent Pilot Trial[J]. J Am Coll Cardiol, 1998,31 ( 1 ): 23-30.
  • 2De Luca G, van't Hof AW, Ottervanger JP, et al. Unsuccessful reperfusion in patients with ST-segment elevation myocardial infarction treated by primary angioplasty, Am Heart J,2005,150 ( 3 ) : 557-562.
  • 3Kloner RA, Ganoe CE, Jennings RB. The "no-reflow" phenomenon after temporary coronary occlusion in the dog[J]. J Clin Invest, 1974,54 ( 6 ) : 1496-1508.
  • 4Michaels AD, Gibson CM, Barron HV. Microvascular dysfunction in acute myocardial infarction: focus on the roles of platelet and inflammatory mediators in the no-reflow phenomenon[J]. Am J Cardiol, 2000,85 ( 5A ) : 50b-60b.
  • 5Engler RL, Schmid-Schonbein GW, Pavelec RS. Leukocyte capillary plugging in myocardial ischemia and reperfusion in the dog[J]. Am J Pathol, 1983,111 ( 1 ): 98-111.
  • 6Rezkalla SH, Kloner RA. No-reflow phenomenon[J]. Circulation,2002,105 ( 5 ) : 656-662.
  • 7Galinanes M, Lawson CS, Ferrari R, et al. Early and late effects of leukopenic reperfusion on the recovery of cardiac contractile function. Studies in the transplanted and isolated blood-perfused rat heart[J]. Circulation, 1993,88( 2 ):673-683.
  • 8Lindal S, Sorlie D, Jorgensen L. Endothelial cells of the cardiac microvasculature during and after cold cardioplegic ischaemia. Comparison of endothelial and myocyte damage[J]. Scand J Thorac Cardiovasc Surg, 1988,22 ( 3 ) : 257-265.
  • 9Reynolds JM, McDonagh PF. Early in reperfusion, leukocytes alter perfused coronary capillarity and vascular resistance[J]. Am J Physiol, 1989,256 ( 4 Pt 2 ) : H982-989.
  • 10Pudil R, Pidrman V, Krejsek J, et al. Cytokines and adhesion molecules in the course of acute myocardial infarction[J]. Clin Clim Acta, 1999,280 ( 1-2 ) : 127-134.

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