感染性肺炎病儿血清IL-17和IL-10水平变化及意义

CHANGES OF SERUM INTERLEUKIN-10 AND INTERLEUKIN-17 IN CHILDREN WITH INFECTIOUS PNEUMONIA

目的探讨感染性肺炎病儿血清白细胞介素17(IL-17)和白细胞介素10(IL-10)水平变化及临床意义。方法 2011年10月—2012年9月,选择我院儿科住院感染性肺炎病儿70例(重症肺炎组30例,轻症肺炎组40例)为研究对象,同期选择健康体检儿童20例作为对照组。应用ELISA法检测两组血清IL-17、IL-10水平的变化。结果重症肺炎组血清IL-17、IL-10水平较正常对照组明显升高,差异有显著性(F=11.02、10.20,q=5.96、5.74,P<0.01);重症肺炎组血清IL-17、IL-10水平明显高于轻症肺炎组,差异有显著性(q=4.86、5.67,P<0.01)。肺炎恢复期病儿血清IL-17水平较急性期明显降低,差异有显著性(t=4.537,P<0.01);而肺炎病儿急性期血清IL-10水平与恢复期比较,差异无显著性(P>0.05)。重症肺炎急性期病儿血清IL-17升高幅度明显大于血清IL-10升高幅度,差异有显著性(t=3.890,P<0.01)。结论感染性肺炎病儿急性期存在免疫功能紊乱,血清IL-17水平显著增高且与病情严重程度相关,而血清IL-10水平虽呈保护性升高但重症病儿反应不明显。

Objective To assess the clinical significance of changes of serum cytokines IL-17 and IL-10 in children with infectious pneumonia. Methods A total of 70 children with pneumonia hospitalized in our hospital during Oct. 2011 Dec.2012 were selected. Of whom, 30 were with severe infection and 30 with mild infection. Twenty healthy children of corresponding time period served as controls. IL-17 and IL-10 were detected by using ELISA. Results The levels of IL-17 and IL-10 in the severe group were higher than that in the normal group （F=11.02,10.20;q=5.96,5.74;P〈0.01） and the mild group （q=4.86,5. 67; P〈0.01）. The level of IL-17 in recovery stage was lower than that in acute stage （t =4.537,P〈0.01）. No significant difference of IL-10 level was found between acute stage and recovery stage （P〉0.05）. The extent of elevation of IL-17 in acute stage was higher than IL-10 （t=3.890,P〈0.01）. Conclusion There is an immunologic function disorder in acute stage of infectious pneumonia, the serum level of IL-17 rises and correlates with the severity of the disease, though the level of IL-10 shows protective elevation, the severe sick kids do not react obviously.