老年阻塞性睡眠呼吸暂停综合征与糖尿病关系随访研究

Follow-up: the correlation between obstructive sleep apnea syndrome and diabetes in the elderly

目的观察阻塞性睡眠呼吸暂停综合征(OSAS)与糖尿病的关系。方法对1868例人群进行前瞻性随访,通过家访式调查,随访期间每年进行1次体检,检查血压、血脂、血糖、心电图及X线胸片等,随访时间为20年。结果 1868例确诊OSAS者598例(32.0%),对照组(无OSAS)1270例(68.0%)。随访终点OSAS组、糖耐量异常181例(31.3%)、糖尿病157例(26.3%),较对照组174例(13.7%)、128例(10.1%)差异有显著性(P<0.01)。结论 OSAS患者发生糖尿病可能性较一般人群高,考虑OSAS与糖尿病发生存在相关性。提示OSAS可能是糖尿病的独立危险因素,可能促发糖尿病的发生。

Objective To explore the correlation between obstructive sleep apnea syndrome（OSAS） ana diabetes. Method Prospective Home-visit questionaires for 1868 elderly people were used from November 1989 to November 2009, accompanied by annual medical examinations including blood pressure, blood-fat, serum glucose, electrocardiogram and chest X-ray. Computer tomography was carried out When diabetes manifested, that was termination of follow-up, the period of follow-up lasted 20 years. Result Among 1868 elderly people, 598 （ 32.0% ） OSAS patients were made a definite diagnosis, in which 496 （ 82.9% ） were male, 102 （ 17.1% ） were female. Compared with 1270 （68.0%） non-OSAS group,patients who developed into diabetes were 157（26.3% ）例 in OSAS group, and 128 （10.1% ,P〈0.01 ） in non-OSAS group,respectively. Conclusion According to longtime follow-up, the probability of OSAS patient suffers from diabetes is larger than the normal. We consider that there is a correlation between OSAS and diabetes. At the end of our 20 years follow-up, OSAS may be an independent dangerous factor of diabetes.