2型糖尿病患者胰岛素抵抗与颈动脉粥样硬化的关系

Relationship between the insulin resistance of type 2 diabetes mellitus and carotid atherosclerosis

目的探讨2型糖尿病患者胰岛素抵抗与颈动脉粥样硬化的关系。方法连续入选在我院住院的60例2型糖尿病患者,测定其血压、血脂、BMl、糖化血红蛋白(HbAlc)、空腹血糖(FBG)、空腹胰岛素(FINS),并计算胰岛素抵抗指数(HOMA—IR)及胰岛素释放曲线下面积(AUC),超声测量颈动脉内膜中层厚度(IMT),依据HOMA—IR高低将患者分为3组。结果 IMT与病程、FBG、FINS、I-IOMA—It/及AUC独立相关,与BMl、HbAlc、收缩压(SBP)及高密度脂蛋白(LOL)无明显相关关系结论 2型糖尿病患者IMT与胰岛素抵抗及血糖控制程度密切相关。测量方法简单,对2型糖尿病患者胰岛素抵抗及心血管并发症有一定预测作用。

Objective： To investigate the relationship between the insulin resistance of type 2 diabetes meUitus and carotid atheresclerosis. Methods： Carotid intimamedia thickness （IMT）, plaque and other index were examined by type - B uhrasonicd in 60 patients with type 2 diabetes mellitus. Results： The incidence rate of IMT and plaque in group of patients with insulin resistance were significantly higher than the group of patients without insulin resistance. Conclusion： The carotid atheresclerosis degree is related with the insulin resistance in patients with type 2 diabetes mellitus.