阿托伐他汀对急性自发性脑出血血清S-100β蛋白水平的影响研究

Effects of atorvastatin on serum levels of S-100β in acute cerebral spontaneous hemorrhage

目的观察阿托伐他汀对急性脑出血患者血清S-100β蛋白的影响,探讨阿托伐他汀对急性脑出血脑保护作用。方法 82例脑出血患者按血肿量大小分为未手术组、微创血肿穿刺引流组、开颅血肿清除组。实验组患者在待病情稳定后,加用阿托伐他汀20 mg鼻饲或口服,每日1次治疗。所有患者起病第1、2、3、5、7天分别抽取空腹外周静脉血,双抗体夹心ELISA法测定血清S-100β蛋白。结果 3组患者血清S-100β蛋白水平分别为(0.452±0.047)μg/L、(0.804±0.063)μg/L、(3.082±0.065)μg/L,逐渐增高,差异有显著性。三组患者中的实验组与其相应对照组相比,血清S-100β蛋白水平随着时间延长,下降明显,差异有显著性。结论阿托伐他汀能够降低急性脑出血患者血清S-100β蛋白水平,阿托伐他汀对急性脑出血发挥治疗保护作用。

Objective To observe the influence of atorvastatin on serum levels of S-100β concentrations in cerebral spontaneous hemorrhage to study its protection mechanisms for cerebral spontaneous hemorrhage. Method Eighty- two patients with cerebral hemorrhage were divided into three groups according to hematoma quantity： conservative treatment group; mini-invasive hematoma aspiration group; craniotomy and hematoma evacuation group; patients in experimental group were given atorvastatin 20 mg per day , all patients＇ serum levels of S-100β concentrations were measured on 1,2,3,5,7 days by ELISA. Result The serum levels of S-100β of three groups（ conservative treatment group; mini-invasive hematoma aspiration group; craniotomy and hematoma evacuation group） were （0. 452 ±0. 047）μg/L, （0. 804±0. 063 ）μg/L, （3. 082±0.065 ） μg/L respectively; within each groups, the S-100β concen-trations of the experimental groups decreased significantly compared with those of the control groups. Conclusion Atorvastatin can decrease the serum levels of S-100β and may have protecting functions on cerebral spontaneous hemorrhage.