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脂肪细胞三酰甘油分解代谢相关调节的研究进展 被引量：10

Research progress in regulation of triglyceride hydrolysis in adipocytes
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摘要 脂肪组织是体内重要的能量储存和供应站,脂肪细胞中的三酰甘油分解代谢紊乱与肥胖等代谢疾病密切相关。在多种脂肪分解途径中,有许多机制尚未明确。已知激素敏感性脂肪酶、脂肪三酰甘油脂肪酶是重要的脂肪细胞三酰甘油水解酶,围脂滴蛋白是脂肪分解的重要调节因子。本综述将着重介绍脂肪细胞三酰甘油分解代谢的主要调节通路和上述酶及蛋白作用机制方面的研究进展。 Adipose tissue is an important station for energy storage and service in the body.The dysregulation of triglyceride hydrolysis is related to obesity and other lipid metabolism disorders.Hormone-sensitive lipase（HSL） and adipose triacylglycerol lipase（ATGL） are major enzymes for triglyceride hydrolysis.Perilipin is an important regulatory factor for lipolysis.This review summarized advance in research on the main regulatory pathway for triglyceride hydrolysis and the roles of HSL,ATGL,and perilipin in triglyceride hydrolysis in adipocytes.
作者 黄文钰 李向平
机构地区 中南大学湘雅二医院心内科
出处 《国际病理科学与临床杂志》 CAS 2013年第3期230-234,共5页 Journal of International Pathology and Clinical Medicine
关键词 脂肪细胞 三酰甘油 激素敏感性脂肪酶 脂肪三酰甘油脂肪酶 围脂滴蛋白 adipocytes triglyceride hormone-sensitive lipase adipose triacylglycerol lipase perilipin
分类号 R363 [医药卫生—病理学]
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  • 1Holm C. Molecular mechanisms regulating hormone-sensitive lipase and lipolysis [J]. Biochem Soc Trans, 2003, 31(Pt 6) : 1120-1124
  • 2Wang S P, Laurin N, Himms-Hagen J, et al. The adipose tissue phenotype of hormone-sensitive lipase deficiency in mice [ J]. Obes Res, 2001, 9(2): 119-128
  • 3Haemmerle G, Zimmermann R, Hayn M, et al. Hormone-sensitive lipase deficiency in mice causes diglyceride accumulation in adipose tissue, muscle, and testis [J]. J Biol Chem, 2002, 277(7) : 4806- 4815
  • 4Zimmermann R, Strauss J G, Haemmerle G, et al. Fat mobilization in adipose tissue is promoted by adipose triglyceride lipase [ J ]. Science, 2004, 306(5700): 1383-1386
  • 5Jenkins C M, Mancuso D J, Yan W, et al. Identification, cloning, expression, and purification of three novel human calciumindependent phospholipase A2 family members possessing triacylglycerol lipase and acylglycerol transacylase activities [ J ]. J Biol Chem, 2004, 279(47): 48968-48975
  • 6Villena J A, Roy S, Sarkadi-Nagy E, et al. Desnutrin, an adipocyte gene encoding a novel patatin domain-containing protein, is induced by fasting and glucocorticoids: ectopic expression of desnutrin increases triglyceride hydrolysis [J]. J Biol Chem, 2004, 279(45) : 47066-47075
  • 7Kershaw E E, Harem J K, Verhagen L A, et al. Adipose triglycefide lipase: function, regulation by insulin, and comparison with adiponutrin [J].Diabetes, 2006, 55(1): 148-157
  • 8Jaworski K, Sarkadi-Nagy E, Duncan RE, et al. Regulation of triglyceride metabolism. IV. Hormonal regulation of lipolysis in adipose tissue [J].Am J Physiol Gastrointest Liver Physiol, 2007, 293(1) : G1-4
  • 9Zechner R, Kienesberger P C, Haemmerle G, et al. Adipose triglyceride lipase and the lipolytic catabolism of cellular fat stores [J]. J Lipid Res, 2009, 50(1): 3-21
  • 10Langin D, Dicker A, Tavernier G, et al. Adipocyte lipases and defect of lipolysis in human obesity [J]. Diabetes, 2005, 54 ( 11 ) : 3190-3197

共引文献10

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国际病理科学与临床杂志
2013年 第3期

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