血清25羟维生素D3与成纤维细胞生长因子23在2型糖尿病合并高血压患者中变化趋势的观察

A study on the changes in levels of serum 25-hydroxyvitamin D3 and fibroblast growth factor-23 in the T2DM patients with hypertension

目的了解血清25羟维生素D3[25-(OH)D3]与成纤维细胞生长因子23(FGF23)水平在T2DM合并高血压患者中的变化趋势。方法选取T2DM合并高血压患者40例(DH组),单纯T2DM患者40例(T2DM组),以及同期体检的健康者40名(NC组),检测血清25-(OH)D3和FGF23水平及各项临床生化指标。结果 T2DM组血清25-(OH)D3水平[(31.96±2.13)μg/L]低于NC组[(33.53±2.53)μg/L](P<0.05),DH组25-(OH)D3水平[(30.82±2.83)μg/L]较T2DM组更低(P<0.01)。T2DM组FGF23水平[(1.80±0.09)μg/L]高于NC组[(1.14±0.09)μg/L](P<0.01),DH组FGF23水平[(1.86±0.08)μg/L]较T2DM组更高(P<0.01)。结论血清25-(OH)D3和FGF23水平与T2DM合并高血压有相关性。

Objective To detect the changes in levels of serum 25-hydroxyvitamin 133 [25-（OH）D3] and fibroblast growth factor-23 （FGF23） in the T2DM patients with hypertension. Methods Forty T2DM patients with hypertension （DH group）, 40 T2DM patients without hypertension （T2DM group）, and 40 healthy subjects （NC group） were involved in this trial. The measurements of serum 25-（OH）D3 and FGF23 and other clinical biochemical indices were performed for all patients and subjects for observation. Results The level of serum 25-（OH）D3 was lower in the T2DM group[（31.96±2. 13）μg/L] than in the NC group E（33.53-I-2.53）μg/L] （P〈0. 05）, and the level of serum 25-（OH）D3 was lower in the DH group [（30. 82±2. 83）μg/L] than in the T2DM group （P〈0. 01）. The level of serum FGF23 in the T2DM group was [（1.80±0. 09）μg/L] , higher than in the NC group [（1.14±0.09）μg/L] （P〈 0. 01）, and the level of serum FGF23 of the DH group was [（1.86±0. 08）μg/L] , higher than in T2DM group （P〈0.01）. Conclusion The levels of serum 25-（OH）D3 and FGF23 are related to the T2DM accompanied with hypertension.