羟考酮控释片联合复方苦参注射液治疗中重度癌性疼痛的临床观察

Clinical study of Oxycodone combined with composite radix sophora flavescentis injection in the pain-relieving of moderate to severe cancer

目的观察羟考酮控释片联合复方苦参注射液治疗中重度癌性疼痛的有效性及不良反应的发生。方法将87例伴有中重度疼痛的恶性肿瘤患者随机分为治疗组和对照组,分别给予羟考酮控释片联合复方苦参注射液和羟考酮控释片单药治疗。结果两组均能有效地控制癌痛,治疗组与对照组疼痛缓解率无统计学意义(P>0.05),分别为97.7%和92.9%;而治疗组不良反应发生率明显低于对照组,差异有统计学意义(P<0.05)。结论羟考酮控释片联合复方苦参注射液能有效地控制恶性肿瘤患者的中重度疼痛,可以减少羟考酮控释片的不良反应,提高患者的生活质量。

【Objective】 To explore the effects and reaction of Oxycodone combined with radix sophora flavescentis injection.【Methods】 Ninety-eight patients with moderate to severe cancer pain were randomly divided into the observation group and the control group by single blind randomized controlled trial with Oxycodone,combined with composite radix sophora flavescentis injection or alone,administered respectively.【Results】 Control rates of cancer pain were similar in both two groups（97.7% vs 92.9%,P ＆gt;0.05）.However,incidence rate of adverse effects in the observation group,was significant lower than in the control group（P ＆lt;0.05）.【Conclusion】 Oxycodone combined with composite radix sophora flavescentis injection may relieve the pain of moderate to severe lung cancer and hence,adverse effects of Oxycodone,which in turn improves the quality of life of the patients.