期刊文献+

抗结核药物肝损害的临床分析 被引量:3

下载PDF
导出
摘要 目的探讨抗结核药物性肝损害的临床特点及易感因素。方法回顾性分析915例结核病患者发生抗结核药物性肝损害的临床特点及相关因素。结果 915例初治结核患者中,130例(14.2%)发生抗结核药物性肝损害,其中≥60岁、女性、化疗初始接受护肝治疗者抗结核药药物性肝损害发生率显著高于<60岁、男性、未接受护肝治疗患者。结论女性、高龄是抗结核药物性肝损害的易感因素;合理使用护肝药物有可能减低易感患者的抗结核药物性肝损害的发生率。
出处 《现代中西医结合杂志》 CAS 2013年第21期2360-2362,共3页 Modern Journal of Integrated Traditional Chinese and Western Medicine
  • 相关文献

参考文献8

二级参考文献79

共引文献383

同被引文献37

  • 1王铁琼.抗结核药致肝损害的相关因素分析[J].中国医药指南,2010,8(14):290-291.
  • 2Hussain Z,Kar P,Husain SA.Antituberculosis druginduced hepatitis:risk factors,prevention and management[J].India J Exp Boil,2003,41(11):1226-1232.
  • 3Chang KC,Leung CC,Yew WW,et al.Hepatotoxicity of pyrazi-namide:cohort and case-control analysis[J].Am J Respir Crit Care Med,2008,177(12):1391-1396.
  • 4Tostmann A,Boeree MJ,Aamoutse RE,et al.Antituberculosis druginduced hepatotoxicity:concise up-to-date review.J Gastroenterol Jepatol,2008,23(2):192-202.
  • 5Makhlouf HA,Helmy A,Fawzy E,et al.A prospective study of antituberculous drug-induced hepatotoxicity in an area endemic for liver diseases[J].Hepatol Int,2008,2(3):353-360.
  • 6Singla R,Sharma SK,Mohan A,et al.Evaluation of risk factors for antituberculosis treatment induced hepatotoxicity[J].Indian J Med Res,2010,132(1):81-86.
  • 7罗如平,刘静,于四景,罗俊明,牟刚.儿童抗结核药物肝毒性反应的相关因素分析[J].医学临床研究,2007,24(12):2139-2141. 被引量:4
  • 8Chamorro JG, Castagnino JP, Musella RM, et al. Sex, ethnieity, and slow acetylator profile are the major causes of hepatotoxicity induced by antituberculosis drugs [ J]. J Gastroen Hepatol,2013, 28(2) : 323 -328.
  • 9Corsini A, Bortolini M. Drug-induced liver injury: the role of drug metabolism and transport[J]. J Clin Pharmacol, 2013,53 (5) :463-474.
  • 10Leise MD, Poterucha JJ, Talwalkar JA. Drug-induced liver injury [-J] . Mayo Clin Proc, 2014, 89 (1):95-106.

引证文献3

二级引证文献9

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部