摘要
以聚酰胺-胺(PAMAM)为模板制备了粒度可控的聚酰胺-胺/硫化铋(PAMAM/Bi2S3)复合纳米粒子,所得复合纳米粒子用紫外可见吸收光谱(UV-Vis)和高分辨透射电镜(HRTEM)等手段进行表征。结果表明,以酯基为端基的半代树形聚合物(Gn.5)制备的PAMAM/Bi2S3复合纳米粒子分散比较均匀,粒度很小,并且粒径可通过调节实验条件(如铋源种类、PAMAM的端基性质、硫化钠浓度、反应温度、反应物配比、PAMAM的代数等)进行调控。细胞培养实验表明,G5.5PAMAM/Bi2S3复合纳米粒子无细胞毒性,可以应用于CT造影剂等生物领域。
PAMAM/Bismuth sulfide （Bi2S3 ） hybrid nanoparticles with controllable diameters were obtained utilizing different generations of poly（amidoamine） （PAMAM） dendrimers as templates. The obtained PAM- AM/Bi2S3 hybrid nanoparticles formed by half-generation PAMAM dendrimers and bismuth nitrate were characterized by high resolution transmission electron microscopy （HRTEM） and UV-Vis absorption spectroscopy. The data indicated that they were small and nearly monodispersed particles and their size could be tuned by changing the synthesis conditions such as bismuth precursors, terminal groups of PAMAM, Na2S concentration, reaction temperature,PAMAM/Bi^3＋ ratio and PAMAM generation. Cell culture experiments indicated that G5.5 PAMAM/Bi2S3 hybrid nanoparticles had no cytotoxicity,which could be applied in biological fields such as CT contrast agent.
出处
《化学与生物工程》
CAS
2013年第7期25-28,共4页
Chemistry & Bioengineering
基金
国家自然科学基金资助项目(31070886)
