哌嗪基噁唑烷酮类衍生物的合成及其体外抗菌活性研究

Study on Synthesis and Antibacterial Activity of Piperazinyl Oxazolidinone Derivatives in vitro

以S-环氧氯丙烷和3,4-二氟硝基苯为原料,设计并合成了12个哌嗪取代噁唑烷酮类化合物,其结构均经高分辨1 HNMR和MS确认。以利奈唑胺为参照物,对合成的化合物进行了金黄色葡萄球菌、链球菌和大肠杆菌的体外抗菌实验,结果表明,合成的化合物有一定抗菌活性,但活性均明显低于利奈唑胺。

Using S-epic.hlorohydrin and 3,4-difluoro-nitrobenzene as raw materials, twelve piperazme substituted oxazolidinone compounds were synthesized. Their structures were confirmed by high resolution 1HNMR and MS. With linezolid as the reference,the antibacterial test in vitro showed that these compounds had certain antibacterial activities against Staphylococcus aureus and Streptococcus. However, the antibacterial activities were significantly lower than that of linezolid.