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Lynch综合征诊治进展 被引量:3

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摘要 Lynch综合征是最常见的遗传性大肠癌,属于常染色体显性遗传疾病。早在1913年美国学者Warthin首先报道了一个Lynch综合症家系,特征为家族多发的非息肉性结肠癌,同时伴有高发的胃癌和子宫癌。1966年,Lynch等[1]报道了2个大家系的Lynch综合征病例。
出处 《河北医药》 CAS 2013年第14期2185-2186,共2页 Hebei Medical Journal
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参考文献13

  • 1Lynch HT,Lynch PM,Lanspac SJ,et al. Review of the Lynch syndrome: history,molecular genetics, screening, differential diagnosis, and medico- legal ramifications. Clin Genet ,2009,76 : 1-18.
  • 2Vasen HFA, Moslein G, Alonso A, et al. Guidelines for the clinical man- agement of Lynch syndrome ( hereditary non-polyposis cancer ). J Med Genet, 2007,44 : 353 -362.
  • 3Laghi L, Bianchi P, Roncalli M, et al. Revised Bethesda guidelines for he- reditary nonpolyposis eolorectal cancer (Lynch syndrome) and microsat- ellite instability. J Natl Cancer Inst ,2004 ,96 : 1402-1403.
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  • 8Lindor NM,Rabe K,Petersen GM, et al. Lower cancer incidence in Am- sterdam-I criteria families without mismatch repair deficiency: Familial colorectal cancer type X. JAMA,2005,293 : 1979-1985.
  • 9Ka|ady MF, McGannon E, Vogel JD. Risk of colorectal adenoma and car- cinoma after colectomy for colorectal cancer in patients meeting Amster- dam criteria. Ann Surg,2010,252:507-511.
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