摘要
The synthesis of sodium glycidazole yields three products detected by HPLC. Electrospray ionization mass spectrometry has been successfully applied to identify the three products. ESI mass spectrometry demonstrated that the first component is 2-nitro-5-emthylimidazole as impurity and the third component is the target compound, sodium glycidazole, as main product. The second and the third components were further investigated by the scanning of the daughter ion at m/z 373[M+H]+, m/z 520[M+H]+ using ESI tandem mass spectrometry. The experimental results show that the second component has the structure similar to the desired product but without one imidazolering.
The synthesis of sodium glycidazole yields three products detected by HPLC. Electrospray ionization mass spectrometry has been successfully applied to identify the three products. ESI mass spectrometry demonstrated that the first component is 2-nitro-5-emthylimidazole as impurity and the third component is the target compound, sodium glycidazole, as main product. The second and the third components were further investigated by the scanning of the daughter ion at m/z 373[M+H]+, m/z 520[M+H]+ using ESI tandem mass spectrometry. The experimental results show that the second component has the structure similar to the desired product but without one imidazolering.
出处
《质谱学报》
EI
CAS
CSCD
2000年第3期125-126,共2页
Journal of Chinese Mass Spectrometry Society
