临床分离100株肺炎链球菌的分布及耐药性分析

Antibiotics susceptibility analysis of one hundred clinical streptococcus pneumoniae isolates

目的:探讨临床分离的肺炎链球菌对抗菌药物体外敏感性,为临床合理用药提供参考。方法:对临床分离的100株肺炎链球菌的来源分布和药敏情况进行统计分析。结果:多种临床标本均可分离到肺炎链球菌,其中主要来自痰液标本(96.0%);在住院病房中,以儿科(85%)的分离率最高,其次是内科(6%);100株肺炎链球菌中,青霉素不敏感菌株有41株,占41.0%;对红霉素、复方新诺明和克林霉素的耐药率较高,分别为47%、42%和34%,而对万古霉素、左氧氟沙星、头孢三嗪和亚胺培南的敏感性较好,敏感率分别为95%、90%、83%、83%,此外青霉素不敏感的菌株与青霉素敏感的菌株相比,更容易表现出多重耐药性。结论:医院临床分离的肺炎链球菌对青霉素的耐药性比较严重,四环素和红霉素已不是治疗肺炎链球菌的有效药物,新的哇诺酮类药物对肺炎链球菌有很强的抗菌作用。

Objective：To investigate the in vitro antimicrobial susceptibility of Streptococcus pneumoniae and guide the rational use of drug clinically.Methods： Statistical analysis of the susceptibility of 100 strains of S.pneumoniae isolated was performed in our hospital from Feb.,2009 to Jan.,2010.Results： S.pneumoniae could be isolated from various specimens,most of them were isolated from sputum（96.0%）.S.pneumoniae could be detected from many hospital wards,but more strains isolated from pediatric（85.0%） and respiratory（6.0%） departments.A total of 41.0% of S.pneumoniae isolates were penicillin non-susceptible,the resistance prevalence to erythromycin was 47.0%,totrimethoprim / sulfamethoxazole 42.0% and to Clindamycin 34%,while they were highly susceptible to vancomycin（95.0%）,levofloxacin（90.0%）,Ceftriaxone（83.0%） and lmipenem（83.0%）.Conclusions： The resistance to penicillin of S.pneumoniae is serious in our hospital.The tetracycline and erythromycin are not the best choice in treating S.pneumoniae infection,and the new fluroquinolones show strong activity against S.pneumoniae.