杂多配合物抗狐脑炎病毒的活性探讨

Activity of Heteropoly Compounds for Anti-Fox encephalitis Virus

合成 10种杂多配合物 ,采用细胞培养法 ,测定了各化合物对狗肾细胞的毒性及在无毒浓度下 ,抗狐脑炎病毒 ( FEV)活性 ,结果表明 ,部分化合物在无毒浓度下 ,具有较强的抗狐脑炎病毒活性 ,两种化合物 HPC- 1,HPC- 9显示出很高的效力和选择性 ,其中 ,化合物 HPC- 9的半数有效浓度为 8mg/ L,半数中毒浓度在 530 mg/ L,抗病毒指数为 66,并对化合物抗病毒机理进行了探讨 .

Ten heteropoly compounds were synthesized. Their toxicity to the cells of dog kidney and activity for anti-fox encephalitis virus at nontoxic concentrations were tested by cell culture method. Some of the compounds had high anti-FEV activity at nontoxic concentration, among them HPC-9 had IC_50 of 8 mg/L, TC_50 of 530 mg/L and TI of 66. The antivirus mechanism of the compounds has been discussed briefly.