摘要
目的利用GC-MS法比较温莪术传统水煎液与挥发油所含挥发性成分的差别,初步探讨水煎剂中的主要化学成分,为温莪术水煎剂临床疗效物质基础研究积累数据,为温莪术挥发油及其制剂的临床用药给予指导。方法采用GC-MS法对温莪术挥发油和水煎液的乙酸乙酯萃取物化学成分进行分析,通过标准谱库检索结合文献分析,确定温莪术挥发油与水煎液乙酸乙酯萃取物中所含的主要挥发性成分,并对二者所含化学成分进行比较。结果从温莪术挥发油中指认出49种化学成分,从温莪术水煎液乙酸乙酯萃取物中指认出28种化学成分,其中仅有莪术二酮(curdi-one)、斯巴醇(spathulenol)和deoxysericealactone等3种成分为二者共有成分。结论温莪术挥发油与水煎液所含挥发性成分存在显著差别,温莪术水煎液的有效成分需进一步研究。
Objective Using an GC-MS method to determine the volatile oil difference between Curcuma wenyujin and the Curcuma wenyujin decoction,preliminary study the main chemical components of the Curcuma wenyujin decoction,accumulate data for the clinical study on the material foundation of Curcuma wenyujin decoction and give direction to the clinical application of volatile oil from Curcuma wenyujin and its preparations. Methods an GC-MS method was established to analysis the volatile oil chemical composition of Curcuma wenyujin and the ethyl acetate part of Curcuma wenyujin decoction,their chief volatile oil components were determined by searching standard spectrum library combine with literature review. Results 49 compounds were identified in volatile oil of Curcuma wenyujin,and 28 compounds from the ethyl acetate part of Curcuma wenyujin decoction were confirmed. Conclusions There exists significant difference about the volatile oil between Curcuma wenyujin and the ethyl acetate part of Curcuma wenyujin decoction,the therapeutic components in Curcuma wenyujin decoction need further study.
出处
《沈阳药科大学学报》
CAS
CSCD
北大核心
2013年第7期532-536,555,共6页
Journal of Shenyang Pharmaceutical University
关键词
温莪术挥发油
温莪术水煎液
气相-质谱法
挥发性成分差别
volatile oil from Curcuma wenyujin
the ethyl acetate part of Curcuma wenyujin decoction
GC-MS
volatile oil difference