含羟基手性大环多胺化合物的合成及性质表征

The Synthesis and Characterization of Chiral Hydroxyl Amine Macrocyclic Compounds

以4-叔丁基苯酚为原料,与六次甲基四胺在三氟乙酸中反应生成4-叔丁基-2,6-二甲酰苯酚,然后再与环己二胺反应生成Schiff碱,最后通过硼氢化钠使Schiff碱还原成所需化合物.各中间体和目标产物经FT-IR和1H NMR表征确认.

A synthesis method for chiral hydroxyl amine macrocyclic compounds was proposed. Firstly, 4-tert-butyl 2, 6-2-formyl phenol was synthesized by the reaction between 4-tert-butyl phenol and hexamethylenetetramine in tri- fluoroacetic acid. Then the Schiff base was synthesized from the former reaction product with the diaminocyclohex- ane. Finally, the Schiff base was converted into the required compounds by the sodium borohydride. Both the inter- mediate and target products were characterized by IR and ^1H NMR spectra.