血清总IgE和外周血嗜酸性粒细胞在特应性皮炎患者检测中的临床意义

Clinical significance of total serum IgE and peripheral blood eosinophil in detection of atopic dermatitis

目的探讨血清总IgE和外周血嗜酸性粒细胞(EOS)与特应性皮炎(AD)的关系及其在AD检测中的临床意义。方法随机选择2010年5月至2012年1月,在广东省广州市第一人民医院接受治疗的AD患者40例(观察组)和健康体检者40例(健康对照组),分别采用日立7170A全自动生化检测仪和贝克曼库尔特GEN.S全自动血细胞分析仪检测两组患者血清总IgE和外周血EOS浓度,比较和分析两组间IgE和EOS浓度差异及其与AD间的相关性。结果观察组平均IgE和EOS值分别为(1 256.53±1 036.84)U/mL和(569.46±322.13)×106/L,显著高于健康对照组(P<0.05);IgE和EOS与AD易感性关联系数OR值分别达到4.402和3.753,差异均具有统计学意义(P<0.05);IgE和EOS与AD患病程度间呈正相关(P<0.05),相关系数为0.878和0.833;IgE与EOS间呈正相关(P<0.05),相关系数为0.790。结论血清总IgE和EOS与AD的发生和病情活动具有相关性,可为AD临床诊断、综合治疗及疗效评价提供依据。

Objective To investigate the clinical significance of total serum IgE and peripheral blood eosinophils（EOS） in detection of atopic derma（AD）and the relationship between total serum IgE,EOS and AD.Methods 40 cases of AD patients（observation group） and 40 normal cases（control group） in Guangzhou the First People＇s Hospital from May 2010 to January 2012 were randomly selected.The HITACHI 7170A automatic biochemical tester and the BECKMAN COULTER GEN.S automatic blood cell analyzer were used to detect the total serum IgE and peripheral blood EOS concentration in two groups.Comparison and analysis of the differences between IgE and EOS concentration of two groups and their correlation with AD.Results The total serum IgE and EOS concentration of the observation group were（1 256.53±1 036.84） U/mL and（569.46±322.13）×106/L respectively,which were significantly higher than that of control group（P〈0.05）.The correlation coefficient OR value between IgE and EOS and susceptibility of AD reached 4.402 and 3.753 respectively,the difference was statistically significant（P〈0.05）.There was a significant positive correlation between the degree of AD and IgE and EOS and AD prevalence（P〈0.05） and the correlation coefficient reached 0.878 and 0.833;the correlation coefficient between IgE and EOS reached 0.790,which showed significant positive correlation（P〈0.05）.Conclusion There is correlation between total serum IgE,EOS and ocurrence and disease activity in AD,can provide a basis for AD clinical diagnosis,therapy and curative effect evaluation.