导管相关性血流感染的病原菌分布及细菌耐药性分析

Distribution and drug resistance of the pathogens causing in intravascular catheter-related bloodstream infections

目的了解苏州大学附属第三医院血管内导管相关性血流感染(CRBSI)的病原菌分布及细菌耐药情况,为临床提供可靠的诊疗依据。方法对确诊为CRBSI的49例患者回顾性分析其病原菌分布及细菌耐药情况。结果 49例患者共检出49株病原菌,其中革兰阳性菌占61.22%(30/49),以金黄色葡萄球菌和凝固酶阴性葡萄球菌为主;革兰阴性菌占22.45%(11/49),以肠杆菌科和不动杆菌属为主;真菌占16.33%(8/49),均为假丝酵母菌。革兰阳性菌对万古霉素、利奈唑胺的耐药率均为0.00%,对喹奴普丁/达福普丁的耐药率为3.45%;革兰阴性菌对头孢哌酮/舒巴坦和亚胺培南的耐药率分别为9.09%、18.18%;未发现对5-氟胞嘧啶和两性霉素耐药的真菌。结论了解CRBSI感染和药敏有助于预防和指导CRBSI的治疗。

Objective To understand the distribution and drug resistance of the pathogens causing in intravascular catheter-related bloodstream infections（CRBSI）,and provide reliable basis for clinical diagnosis and treatment.Methods A retrospective analysis of the distribution of pathogens and drug resistance in 49 patients with CRBSI diagnosed.Results A total of 49 patients were detected in 49 strains of pathogens,including Gram-positive bacteria accounted for 61.22%（30/49）,mainly in Staphylococcus aureus and coagulase-negative staphylococci;Gram-negative bacteria accounted for 22.45%（11/49）,mainly in Enterobacteriaceae and Acinetobacter;Fungi accounted for 16.33%（8/49）,were Candida.Gram-positive bacteria to Vancomycin,Linezolid resistance rate was 0.00%,to Quinupristin/Dalfopristin resistance rate was 3.45%;Gram-negative bacteria to Cefoperazone/Shubatan and Imipenem resistance rate was 9.09%,18.18% respectively;Not found in fungi,which was resistant to 5-fluorocytosine and amphotericin B.Conclusion To understand the distribution and drug resistance of pathogens causing in intravascular CRBSI,which can contribute to the prevention and treatment of CRBSI.