复方钩藤降压片治疗原发性高血压阴虚阳亢挟瘀证疗效及对CysC、hs-CRP的影响

Effects of compound Gouteng Jiangya tablet on hypertension patients with yin-asthenia and yang-hyperactivity laden stasis syndrome and the expressions of Cys C and hs-CRP

目的探讨复方钩藤降压片对原发性高血压阴虚阳亢挟瘀证患者的临床疗效及作用机制。方法选取原发性高血压阴虚阳亢挟瘀证患者60例,随机分为治疗组和对照组各30例,分别给予复方钩藤降压片与苯璜酸左旋氨氯地平片治疗4周。观察治疗前后血压及相关症状体征的变化,同时检测血清胱抑素C(Cys C)、超敏C反应蛋白(hs-CRP)含量。结果 (1)治疗组、对照组降压总有效率分别为83.3%、86.7%,差异无统计学意义(P>0.05),降压效果相当。(2)治疗组、对照组治疗后证候积分与治疗前比较,差异有统计学意义(P<0.01),且治疗组积分改善优于对照组(P<0.05)。(3)两组治疗2、3、4周后分别与治疗前比较,SBP、DBP下降显著(P<0.05)。(4)两组治疗后Cys C、hs-CRP较治疗前均降低(P<0.05),组间比较差异无统计学意义(P>0.05)。结论复方钩藤降压片治疗高血压病阴虚阳亢挟瘀证患者,能够降低血压水平,提高生活质量,其作用机制可能与降低患者血清Cys C、hs-CRP表达水平相关。

Objective To investigate the clinical effect and mechanism of compound Gouteng Jiangya tablet on hypertension patients with yin-asthenia and yang-hyperactivity laden stasis syndrome.Methods 60 primary hypertension patients with yin-asthenia and yang-hyperactivity laden stasis syndrome were randomly divided into the treatment group and the control group,with 30 cases in each group.The treatment group and control group were respectively given compound Gouteng Jiangya tablets and Levamlodipine Besylate tablets,lasted for 4 weeks.Changes in blood pressure and related symptoms and signs were observed before and after treatment,the contents of serum cystatin C（Cys C） and high-sensitivity C-reactive protein were detected.Results（1） Total effective rates of anti-hypertension in the treatment group and the control group were 80% and 85% respectively,there was no statistical difference between them（P〈0.05）.（2） There were statistical differences in symptom scores in both groups before and after treatment（P0.01）,and integral improvement in treatment group was superior to that of control group.（3） Compared with before treatment,SBP and DBP in both groups reduced markedly after treatment for 2 weeks,3 weeks,4 weeks,respectively（P〈0.05）.（4） Compared with before treatment,Cys C and hs-CRP in both groups were markedly reduced after treatment（both P〈0.05）.However,there were differences between the two groups.Conclusion Compound Gouteng Jiangya tablets could lower blood pressure and improve life quality of hypertension patients with yin-asthenia and yang-hyperactivity hyperactivity laden stasis syndrome,which may be related to the reduction of serum Cys C and hs-CRP.