3-乙酰基吡咯的合成

Synthesis of 3-acetylpyrrole

用吡咯和对甲苯磺酰氯在钾的催化作用下合成 1 -对甲苯磺酰基吡咯 ( ) ,用 与乙酸酐在 Al Cl3催化下进行傅 -克酰化反应合成了 1 -对甲苯磺酰基 -3-乙酰基吡咯 ( ) ,将 碱式水解可得到 3-乙酰基吡咯。用 FT-IR和 1HNMR对产物的结构进行了表征。

The reaction between pyrrole and p toluenesulfonyl chloride catalyzed by potassium gives 1 ( p toluenesulfonyl) pyrrole(Ⅰ).The acetylation of (Ⅰ) catalyzed by AlCl 3 gives 1 ( p toluenesulfonyl) 3 acetyl pyrrole(Ⅱ),which was hydrolyzed under basic condition to gives 3 acetyl pyrrole(Ⅲ).The structure of the reaction product was determined by FT IR and 1HNMR spectroscopy.