非对称二甲基精氨酸与外周动脉硬化闭塞症的相关性研究

Study on the relationship of ADMA and arterial stiffness and aortic calcification in PAD patients

目的探讨外周动脉硬化闭塞症(PAD)患者血清非对称二甲基精氨酸(ADMA)的水平,主动脉脉搏波传导速度(aPWV)以及主动脉钙化以及它们的相关性。方法测定65例PAD患者和62例健康体检者的血脂、血糖、炎症标记物以及ADMA的水平,所有患者均行肱\主动脉脉搏波传导速度(b\aPWV)的测定、主动脉CT平扫检查,计算主动脉钙化积分。结果 PAD患者aPWV和ADMA较健康体检组显著增高,主动脉钙化积分(ACS)分别与aPWV和ADMA呈正相关,ADMA和aPWV之间也呈正相关。结论 ADMA可能是PAD的危险因素之一。

Objective】Observed the level of the plasma asymmetric dimethylarginine（ADMA）,and it＇s relationship with aortic Pulse Wave Velelocity（aPWV） and aortic calcification in peripheral arterial disease（PAD） patients.【Methods】Measured the levels of plasma cholesterol/triglycerides,glucose,some markers of inflammation and ADMA in 65 PAD patients and 62 healthy controls,each patients also checked Brachial/ aortic pulse wave velocity（b／aPWV） 、aorta CT plain and aortic calcification score（ACS）.【Results】The levels of aPWV and ADMA in PAD group were remarkably increasing than those in control group,while,the level of ACS was positive correlation with the level of aPWV and ADMA separately,and,there was also positive correlation between the levels of ADMA and aPWV.【Conclusions】ADMA might be a significant risk factor in PAD pathogenesis.