糖尿病动脉粥样硬化中巨噬细胞凋亡的研究进展

Research Progress of Macrophage Apoptosis in the Diabetic Atherosclerosis

糖尿病是对人类健康有严重威胁,对社会发展有重大影响的疾病。大多数糖尿病患者死亡与致残的原因为大血管动脉粥样硬化并发症。在动脉粥样硬化性病变的进展过程中,一个关键的步骤就是易损斑块的形成。巨噬细胞凋亡与易损斑块形成密切相关。在晚期动脉粥样硬化病变处,多种信号途径诱导巨噬细胞凋亡,其中内质网应激(ERS)起重要作用。在高血糖、胰岛素抵抗状态下,ERS诱导的巨噬细胞凋亡增加,促进易损斑块的形成,加速动脉粥样硬化性血管疾病的进程。

Diabetes mellitus is a serious threat to human health and has a significant impact on social development.Atherosclerosis,one of the complications of diabetes,which plays a leading role in most diabetes patients＇ disability and even death.A key step is the formation of vulnerable plaque in the atherosclerosis progression.Macrophage apoptosis is closely related to the formation of vulnerable plaque.In the late stage of the atherosclerotic lesions,macrophage apoptosis is induced by multiple signaling pathways,among which endoplasmic reticulum stress plays an important role.Endoplasmic reticulum stress-induced macrophage apoptosis increases in the state of hyperglycemic and insulin resistance,promoting the formation of vulnerable plaque and accelerating the process of atherosclerotic vascular disease.