期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

TLR7在慢性丙型病毒性肝炎中的研究进展 被引量：5

Research Advancement of TLR7 in Chronic Hepatitis C
下载PDF
导出
摘要 Toll样受体7(TLR7)是表达在哺乳动物细胞内的跨膜信号转导受体,通过识别丙型肝炎病毒的单链RNA和多种小分子抗病毒化合物(如isatoribine、imiquimod、R-848等),经MyD88信号通路诱导Ⅰ型干扰素分泌和经非依赖干扰素机制发挥抗丙型肝炎病毒的效应。此外,TLR7的单核苷酸多态性还可能影响着慢性丙型肝炎的肝纤维化进程及干扰素抗丙型肝炎病毒的疗效。该文就TLR7的结构、分布、信号转导通路及其在慢性丙型肝炎病毒感染中发挥的作用作一综述。 Toll like receptor 7 is a transmembrane signal transduction receptor expressed in mammalian cells,which induces type I interferon secretion through the identification of single-stranded RNA of the hepatitis C virus and a variety of small molecule antiviral compounds（such as isatoribine,imiquimod,R-848 etc.） and by the MyD88 signaling pathway,and plays anti-hepatitis C virus effect by non-dependent interferon mechanisms.In addition,Toll like receptor 7 mononucleotide polymorphisms may also affect the process of liver fibrosis of chronic hepatitis C and interferon efficacy against hepatitis C virus.Here is to make a review of the structure,distribution,signaling transduction pathway of TLR7 and its role in chronic hepatitis C virus infection.
作者 王巧凤 韦嘉
机构地区 昆明医科大学第一附属医院感染科
出处 《医学综述》 2013年第13期2336-2339,共4页 Medical Recapitulate
关键词 TOLL样受体7 丙型肝炎病毒感染 激动剂 抗丙型肝炎病毒 Toll like receptor 7 Hepatitis C virus infection Agonist Anti-hepatitis C virus
分类号 R512.63 [医药卫生—内科学]
  • 相关文献

参考文献27

  • 1王豪.丙型肝炎的流行病学与预防[J].中华肝脏病杂志,2003,11(6):366-367. 被引量：38
  • 2Ghany M,Strader D,Thomas D.Diagnosis,management,and treat-ment of hepatitis C:an update[J].Hepatology,2009,49(4):1335-1374.
  • 3Schultheiss M,Thimme R.Toll like receptor 7 and hepatitis C virusinfection[J].J Hepatol,2007,47(2):165-167.
  • 4Du X,Poltorak A,Wei Y,et al.Three novel mammalian toll-likereceptors:gene structure,expression,and evolution[J].Eur Cyto-kine Netw,2000,11(3):362-371.
  • 5Chuang TH,Ulevitch RJ.Cloning and characterization of a sub-family of human toll-like receptors:hTLR7,hTLR8 and hTLR9[J].Eur Cytokine Netw,2000,11(3):372-378.
  • 6Starkel P,De Saeger C,Strain AJ,et al.NFkappaB,cytokines,TLR3 and 7 expression in human end-stage HCV and alcoholic liverdisease[J].Eur J Clin Invest Jul,2010,40(7):575-584.
  • 7Finberg RW,Wang JP,Kurt-Jones EA.Toll like receptors and viru-ses[J].Rev Med Virol,2007,17(1):35-43.
  • 8Hemmi H,Kaisho T,Takeuchi O,et al.Small anti-viral compoundsactivate immune cells via the TLR7 MyD88-dependent signalingpathway[J].Nat Immunol,2002,3(2):196-200.
  • 9Heil F,Ahmad-Nejad P,Hemmi H,et al.The Toll-like receptor 7(TLR7)-specific stimulus loxoribine uncovers a strong relationshipwithin the TLR7,8 and 9 subfamily[J].Eur J Immunol,2003,33(11):2987-2997.
  • 10Hirsch I,Caux C,Hasan U,et al.Impaired Toll-like receptor 7 and9 signaling:from chronic viral infections to cancer[J].TrendsImmunol,2010,31(10):391-397.

二级参考文献17

  • 1RATNAM D, VISVANATHAN K. New concepts in the immunopathogenesis of chronic hepatitis B: the importance of the innate immune response[J]. Hepatol Inter, 2008, 2( 1 ) : 12 - 18.
  • 2ISOGAWA M, ROBEK M D, FURUICHI Y, et al. Toll - Like receptor signaling inhibits hepatitis B virus replication in vivo[ J]. J Virol, 2005, 79( 11 ): 7269- 7272.
  • 3UEMATSU S, AKIRA S. PRRs in pathogen recognition [ J ]. CEJB, 2006, 1(3): 299-313.
  • 4LUND J M, ALEXOPOULOU L, SATO A, et al. Recognition of single - stranded RNA viruses by toll - liker receptor 7 [ J ]. Proc Natl Acad Sci USA, 2004, 101(15) : 5598 -5603.
  • 5THOMAS A, LAXTON C, RODMAN J, et al. Investigating toll - like receptor agonists for potential to treat hepatitis C virus infection [J]. Antimicrobi Agents Chemother, 2007, 51 (8): 2969 - 2978.
  • 6HUI C K, ZHANG H Y, LEE N P, et al. Upregulation of toll - like receptor 7 is essential for serological clearance of hepatitis B surface antigen in chronic hepatitis B virus (HBV) infection[ J ]. Hepatology, 2005, 42(4): 707A.
  • 7LAMPERTICO P, MALTER J S, GERBER M A. Development and application of an in vitro model for screening anti - hepatitis B virus therapeutics [ J ]. Hepatology, 1991, 13 ( 3 ) : 422 - 426.
  • 8颜江瑛,郑锡文,张险峰,刘淑贞,张艺,王存林,刘世亮.我国某县有偿献血员艾滋病病毒感染率调查[J].中华流行病学杂志,2000,21(1):10-12. 被引量：78
  • 9李琳琳,张献清,穆士杰,李翠莹,陈晨.西安地区献血员HGV与HBV及HCV混合感染[J].第四军医大学学报,2000,21(2):146-147. 被引量：4
  • 10胡晶,陈莉,葛红卫,王鸿捷.有偿与无偿献血者血液传染性指标检验结果的比较[J].中国输血杂志,2000,13(2):118-118. 被引量：16

共引文献40

同被引文献66

  • 1黄巧茹.TLR9,先天免疫中重要的抗微生物受体[J].中山大学研究生学刊（自然科学与医学版）,2007,28(3):7-15. 被引量：8
  • 2GHANY M, STRADER D,THOMAS D L. Diagnosis, management, and treatment of hepatitis C : an update [ J ]. Hepatology, 2009,49 (4) :1335 - 1374.
  • 3SCHULTHEISS M ,THIMME R. Toll like receptor 7 and hepatitis C virusinfection[ J ]. J Hepato1,2007,47 (2) : 165 - 167.
  • 4DU X, POLTORAK A, WEI Y, et al. Three novel mammalian toil - like receptors: gene structure, expression, and evolution [ J ]. Eur Cytokine Netw,2000,11 (3) :362 -371.
  • 5BARLAND C O,ZETrERSTEN E,BROWN B S,et al. Imiquimod - induced interleukin - 1 alpha stimulation improves barrier homeosta- sis in aged routine epidermis[ J ]. J Invest Dermatol,2004,122 (2) : 330 - 336.
  • 6BERMAN B, SULLIVAN T, De ARAUJO T, et al. Expression of Fas- receptor on basal eell carcinomas after treatment with imi- quimod 5% cream or vehicle [ J ]. Br J Dermatol, 2003,149 ( Suppl 66) : 59 -61.
  • 7HEIL F, AHMAD - NEJAD P, HEMMI H, et al. The Toll - like re- ceptor 7 (TLR7) - specific stimulus loxoribine uncovers a strong relationship within the TLR7,8 and 9 subfamily[ J ]. Eur J Immunol, 2003,33( 11 ) :2987 -2997.
  • 8JURK M, KRITZLER A, SCHULTE B, et al. Modulating responsive- ness of human TLR7 and 8 to small molecule ligands with T - rich phosphorothiate oligodeoxynucleotides [ J ]. Eur J Immunol, 2006,36 (7) :1815 - 1826.
  • 9MEIER A ,ALTER G,FRAHM N ,et al. MyD88 - dependent immune activation mediated by human immnnodeficiency virus type 1 - enco- ded Tall - like receptor ligands [ J ]. Virol, 2007,81 ( 15 ) : 8180 - 8191.
  • 10SMITS E L, PONSAERTS P, BERNEMAN Z N,et al. The use of TLR7 and TLR8 ligands for the enhancement of cancer immunother- apy[ J]. Oncologist,2008,13 (8) :859 -875.

引证文献5

二级引证文献6

医学综述
2013年 第13期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部