支气管哮喘患儿血清TNF-α、VIP、MTL和GAS检测的临床意义

Clinical Significance of Measurement the Changes of Serum TGF-α,VIP, MTL and GAS Levels in Patients with Bronchial Asthma

目的:探讨支气管哮喘患儿治疗前后血清TNF-α、VIP、MTL和GAS水平的变化及临床意义。方法:应用放射免疫分析对40例支气管哮喘患儿进行了治疗前后血清TNF-α、VIP、MTL和GAS检测,并与35名正常健康儿作比较。结果:支气管哮喘患儿在治疗前血清TNF-α水平非常显著地高于正常儿组(P<0.01),而血清VIP、MTL、GAS水平又非常显著地低于正常儿组(P<0.01),经治疗2周后则与正常儿组比较无显著性差异(P>0.05),血清TNF-α水平与VIP、MTL、GAS水平呈显著负相关(r=-0.6139、-0.5084、-0.5921,P<0.01)。结论:检测支气管哮喘患儿治疗前后血清TNF-α、VIP、MTL和GAS水平的变化对了解支气管哮喘的病理机制及病情评估具有一定的临床意义。

Objective To explore the clinical significance of measurement the changes of serum TNF-α,VIP,MTL,and GAS levels both before and after treatment in pediatric patients with bronchial asthma.Methods Serum TNF-α,VIP,MTL and GAS levels were measured with RIA in all these 40 pediatric patients with bronchial asthma both before and after treatment and compared to 35 normal healthy children as controls.Results Before treatment,serum TNF-α level was significantly higher than that in controls（P 0.01）.But serum VIP,MTL,GAS levels were markedly lower than those in controls（P 0.01）.After 2 week of treatment the levels showed no significant difference from the controls（P 0.05）.Serum TNF-α level expressed negatively correlated with serum VIP,MTL,GAS levels（r =-0.6139,-0.5084,-0.5921,P 0.01）.Conclusion Detection of serum TNF-α,VIP,MTL and GAS levels will be of definite clinical value to realize the pathogenesis of bronchial asthma and assessment of pathosis.